Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles characterized by chromothripsis-amplification.
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Nature Portfolio
2017
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oai:doaj.org-article:4d580842711a47b9a0ba6bb379bd365f2021-12-02T15:38:46ZRecurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma10.1038/ncomms159362041-1723https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15936https://doaj.org/toc/2041-1723Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles characterized by chromothripsis-amplification.Sam BehjatiPatrick S. TarpeyKerstin HaaseHongtao YeMatthew D. YoungLudmil B. AlexandrovSarah J. FarndonGrace CollordDavid C. WedgeInigo MartincorenaSusanna L. CookeHelen DaviesWilliam MifsudMathias LidgrenSancha MartinCalli LatimerMark MaddisonAdam P. ButlerJon W. TeagueNischalan PillayAdam ShlienUltan McDermottP. Andrew FutrealDaniel BaumhoerOlga ZaikovaBodil BjerkehagenOla MyklebostM. Fernanda AmaryRoberto TiraboscoPeter Van LooMichael R. StrattonAdrienne M. FlanaganPeter J. CampbellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
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DOAJ |
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EN |
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Science Q |
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Science Q Sam Behjati Patrick S. Tarpey Kerstin Haase Hongtao Ye Matthew D. Young Ludmil B. Alexandrov Sarah J. Farndon Grace Collord David C. Wedge Inigo Martincorena Susanna L. Cooke Helen Davies William Mifsud Mathias Lidgren Sancha Martin Calli Latimer Mark Maddison Adam P. Butler Jon W. Teague Nischalan Pillay Adam Shlien Ultan McDermott P. Andrew Futreal Daniel Baumhoer Olga Zaikova Bodil Bjerkehagen Ola Myklebost M. Fernanda Amary Roberto Tirabosco Peter Van Loo Michael R. Stratton Adrienne M. Flanagan Peter J. Campbell Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| description |
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles characterized by chromothripsis-amplification. |
| format |
article |
| author |
Sam Behjati Patrick S. Tarpey Kerstin Haase Hongtao Ye Matthew D. Young Ludmil B. Alexandrov Sarah J. Farndon Grace Collord David C. Wedge Inigo Martincorena Susanna L. Cooke Helen Davies William Mifsud Mathias Lidgren Sancha Martin Calli Latimer Mark Maddison Adam P. Butler Jon W. Teague Nischalan Pillay Adam Shlien Ultan McDermott P. Andrew Futreal Daniel Baumhoer Olga Zaikova Bodil Bjerkehagen Ola Myklebost M. Fernanda Amary Roberto Tirabosco Peter Van Loo Michael R. Stratton Adrienne M. Flanagan Peter J. Campbell |
| author_facet |
Sam Behjati Patrick S. Tarpey Kerstin Haase Hongtao Ye Matthew D. Young Ludmil B. Alexandrov Sarah J. Farndon Grace Collord David C. Wedge Inigo Martincorena Susanna L. Cooke Helen Davies William Mifsud Mathias Lidgren Sancha Martin Calli Latimer Mark Maddison Adam P. Butler Jon W. Teague Nischalan Pillay Adam Shlien Ultan McDermott P. Andrew Futreal Daniel Baumhoer Olga Zaikova Bodil Bjerkehagen Ola Myklebost M. Fernanda Amary Roberto Tirabosco Peter Van Loo Michael R. Stratton Adrienne M. Flanagan Peter J. Campbell |
| author_sort |
Sam Behjati |
| title |
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| title_short |
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| title_full |
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| title_fullStr |
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| title_full_unstemmed |
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| title_sort |
recurrent mutation of igf signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f |
| work_keys_str_mv |
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| _version_ |
1718386108197240832 |