Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan

Abstract Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation ca...

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Autores principales:	Abram Bunya Kamiza, Wen-Chang Wang, Jeng-Fu You, Reiping Tang, Huei-Tzu Chien, Chih-Hsiung Lai, Li-Ling Chiu, Tsai-Ping Lo, Kuan-Yi Hung, Chao A. Hsiung, Chih-Ching Yeh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d5c960d35bb4e03a866c9c43b2d7bfd
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spelling	oai:doaj.org-article:4d5c960d35bb4e03a866c9c43b2d7bfd2021-12-02T17:39:32ZCumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan10.1038/s41598-021-88289-22045-2322https://doaj.org/article/4d5c960d35bb4e03a866c9c43b2d7bfd2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88289-2https://doaj.org/toc/2045-2322Abstract Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%–89.9%) and 76.7% (95% CI = 37.2%–99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%–57.7%) and 49.3% (95% CI = 21.9%–84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.Abram Bunya KamizaWen-Chang WangJeng-Fu YouReiping TangHuei-Tzu ChienChih-Hsiung LaiLi-Ling ChiuTsai-Ping LoKuan-Yi HungChao A. HsiungChih-Ching YehNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abram Bunya Kamiza Wen-Chang Wang Jeng-Fu You Reiping Tang Huei-Tzu Chien Chih-Hsiung Lai Li-Ling Chiu Tsai-Ping Lo Kuan-Yi Hung Chao A. Hsiung Chih-Ching Yeh Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
description	Abstract Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%–89.9%) and 76.7% (95% CI = 37.2%–99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%–57.7%) and 49.3% (95% CI = 21.9%–84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.
format	article
author	Abram Bunya Kamiza Wen-Chang Wang Jeng-Fu You Reiping Tang Huei-Tzu Chien Chih-Hsiung Lai Li-Ling Chiu Tsai-Ping Lo Kuan-Yi Hung Chao A. Hsiung Chih-Ching Yeh
author_facet	Abram Bunya Kamiza Wen-Chang Wang Jeng-Fu You Reiping Tang Huei-Tzu Chien Chih-Hsiung Lai Li-Ling Chiu Tsai-Ping Lo Kuan-Yi Hung Chao A. Hsiung Chih-Ching Yeh
author_sort	Abram Bunya Kamiza
title	Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
title_short	Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
title_full	Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
title_fullStr	Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
title_full_unstemmed	Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
title_sort	cumulative risks of colorectal cancer in han chinese patients with lynch syndrome in taiwan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d5c960d35bb4e03a866c9c43b2d7bfd
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Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan

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