Synchronous thyroid gland metastases from breast cancer. Case reports

Background. Breast cancer is the leading cause of death in women. Distant metastases in different organs, including the thyroid gland, are still an urgent problem. Distant metastases are very rare in clinical practice. Nevertheless, the accumulated clinical and surgical experience in treatment has s...

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Autores principales:	Nikolai A. Ognerubov, Tatyana S. Antipova, Elena E. Palkina
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2021
Materias:	thyroid gland breast cancer metastases positron emission tomography/computed tomography Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4d5d32680d954ac982687813003a747c
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spelling	oai:doaj.org-article:4d5d32680d954ac982687813003a747c2021-11-30T16:55:01ZSynchronous thyroid gland metastases from breast cancer. Case reports1815-14341815-144210.26442/18151434.2021.2.200934https://doaj.org/article/4d5d32680d954ac982687813003a747c2021-08-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/71597/pdfhttps://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Background. Breast cancer is the leading cause of death in women. Distant metastases in different organs, including the thyroid gland, are still an urgent problem. Distant metastases are very rare in clinical practice. Nevertheless, the accumulated clinical and surgical experience in treatment has shown that breast cancer is the second most common primary tumor, leading to thyroid gland metastases, after kidney cancer. Aim. Present the clinical observations of synchronous thyroid gland metastases from breast cancer. Materials and methods. We observed two patients, aged 55 and 72 years, suffering from metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical and mediastinal lymph nodes, to the lungs, to the ovaries and to the bones. Results. A 55-year-old woman with a left sided neck mass and hoarseness has been suffering from the metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical lymph nodes, to the lungs, to the ovaries and to the bones. The biopsy of the primary tumor has been performed. The tumor has the structure of invasive ductal carcinoma, G2, luminal A subtype, HER2-negative type in histological and immunohistochemical analysis. The spread of the tumor has been determined by positron emission tomography/computed tomography (PET/CT). Metastases from breast cancer have been cytologically proven during thin needle biopsy. A 72-year-old woman with a mass in the region of thyroid gland has been suffering from breast cancer with metastases to the thyroid gland, to the mediastinal and cervical lymph nodes, to the bones, and to determine this process PET/CT, the thyroid fine needle aspiration biopsy and core biopsy of primary tumor have been applied. The histological variant was represented by invasive ductal cancer, G2, luminal A subtype, HER-2 negative type. Taking into account the spread of the process, the patients were given polychemotherapy, targeted therapy and hormone therapy. There is no disease progression for 6 months. Conclusion. Synchronous thyroid gland metastases in case of primary breast tumors are rare. In such cases, PET/CT is the important diagnostic method. The main therapeutic option in this case is systemic therapy, including chemotherapy, targeted and hormone therapy, the nature of the agent depends on the biological variant of the tumor.Nikolai A. OgnerubovTatyana S. AntipovaElena E. PalkinaIP Habib O.N.articlethyroid glandbreast cancermetastasespositron emission tomography/computed tomographyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 23, Iss 2, Pp 280-286 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	thyroid gland breast cancer metastases positron emission tomography/computed tomography Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	thyroid gland breast cancer metastases positron emission tomography/computed tomography Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nikolai A. Ognerubov Tatyana S. Antipova Elena E. Palkina Synchronous thyroid gland metastases from breast cancer. Case reports
description	Background. Breast cancer is the leading cause of death in women. Distant metastases in different organs, including the thyroid gland, are still an urgent problem. Distant metastases are very rare in clinical practice. Nevertheless, the accumulated clinical and surgical experience in treatment has shown that breast cancer is the second most common primary tumor, leading to thyroid gland metastases, after kidney cancer. Aim. Present the clinical observations of synchronous thyroid gland metastases from breast cancer. Materials and methods. We observed two patients, aged 55 and 72 years, suffering from metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical and mediastinal lymph nodes, to the lungs, to the ovaries and to the bones. Results. A 55-year-old woman with a left sided neck mass and hoarseness has been suffering from the metastatic breast cancer with simultaneous metastases to the thyroid gland, to the cervical lymph nodes, to the lungs, to the ovaries and to the bones. The biopsy of the primary tumor has been performed. The tumor has the structure of invasive ductal carcinoma, G2, luminal A subtype, HER2-negative type in histological and immunohistochemical analysis. The spread of the tumor has been determined by positron emission tomography/computed tomography (PET/CT). Metastases from breast cancer have been cytologically proven during thin needle biopsy. A 72-year-old woman with a mass in the region of thyroid gland has been suffering from breast cancer with metastases to the thyroid gland, to the mediastinal and cervical lymph nodes, to the bones, and to determine this process PET/CT, the thyroid fine needle aspiration biopsy and core biopsy of primary tumor have been applied. The histological variant was represented by invasive ductal cancer, G2, luminal A subtype, HER-2 negative type. Taking into account the spread of the process, the patients were given polychemotherapy, targeted therapy and hormone therapy. There is no disease progression for 6 months. Conclusion. Synchronous thyroid gland metastases in case of primary breast tumors are rare. In such cases, PET/CT is the important diagnostic method. The main therapeutic option in this case is systemic therapy, including chemotherapy, targeted and hormone therapy, the nature of the agent depends on the biological variant of the tumor.
format	article
author	Nikolai A. Ognerubov Tatyana S. Antipova Elena E. Palkina
author_facet	Nikolai A. Ognerubov Tatyana S. Antipova Elena E. Palkina
author_sort	Nikolai A. Ognerubov
title	Synchronous thyroid gland metastases from breast cancer. Case reports
title_short	Synchronous thyroid gland metastases from breast cancer. Case reports
title_full	Synchronous thyroid gland metastases from breast cancer. Case reports
title_fullStr	Synchronous thyroid gland metastases from breast cancer. Case reports
title_full_unstemmed	Synchronous thyroid gland metastases from breast cancer. Case reports
title_sort	synchronous thyroid gland metastases from breast cancer. case reports
publisher	IP Habib O.N.
publishDate	2021
url	https://doaj.org/article/4d5d32680d954ac982687813003a747c
work_keys_str_mv	AT nikolaiaognerubov synchronousthyroidglandmetastasesfrombreastcancercasereports AT tatyanasantipova synchronousthyroidglandmetastasesfrombreastcancercasereports AT elenaepalkina synchronousthyroidglandmetastasesfrombreastcancercasereports
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Synchronous thyroid gland metastases from breast cancer. Case reports

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