TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer

Vasculogenic mimicry (VM) contributes to the development of triple-negative breast cancer. In this study, the authors show that TEM8 is expressed in VM-forming breast cancer stem cells and it promotes stemness and VM differentiation capacity through a RhoC/ROCK1/SMAD5 axis

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Autores principales: Jiahui Xu, Xiaoli Yang, Qiaodan Deng, Cong Yang, Dong Wang, Guojuan Jiang, Xiaohong Yao, Xueyan He, Jiajun Ding, Jiankun Qiang, Juchuanli Tu, Rui zhang, Qun-Ying Lei, Zhi-min Shao, Xiuwu Bian, Ronggui Hu, Lixing Zhang, Suling Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/4d5dff66ab924a66a148c3c003c9bdec
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spelling oai:doaj.org-article:4d5dff66ab924a66a148c3c003c9bdec2021-12-02T17:55:05ZTEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer10.1038/s41467-021-24703-72041-1723https://doaj.org/article/4d5dff66ab924a66a148c3c003c9bdec2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24703-7https://doaj.org/toc/2041-1723Vasculogenic mimicry (VM) contributes to the development of triple-negative breast cancer. In this study, the authors show that TEM8 is expressed in VM-forming breast cancer stem cells and it promotes stemness and VM differentiation capacity through a RhoC/ROCK1/SMAD5 axisJiahui XuXiaoli YangQiaodan DengCong YangDong WangGuojuan JiangXiaohong YaoXueyan HeJiajun DingJiankun QiangJuchuanli TuRui zhangQun-Ying LeiZhi-min ShaoXiuwu BianRonggui HuLixing ZhangSuling LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiahui Xu
Xiaoli Yang
Qiaodan Deng
Cong Yang
Dong Wang
Guojuan Jiang
Xiaohong Yao
Xueyan He
Jiajun Ding
Jiankun Qiang
Juchuanli Tu
Rui zhang
Qun-Ying Lei
Zhi-min Shao
Xiuwu Bian
Ronggui Hu
Lixing Zhang
Suling Liu
TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
description Vasculogenic mimicry (VM) contributes to the development of triple-negative breast cancer. In this study, the authors show that TEM8 is expressed in VM-forming breast cancer stem cells and it promotes stemness and VM differentiation capacity through a RhoC/ROCK1/SMAD5 axis
format article
author Jiahui Xu
Xiaoli Yang
Qiaodan Deng
Cong Yang
Dong Wang
Guojuan Jiang
Xiaohong Yao
Xueyan He
Jiajun Ding
Jiankun Qiang
Juchuanli Tu
Rui zhang
Qun-Ying Lei
Zhi-min Shao
Xiuwu Bian
Ronggui Hu
Lixing Zhang
Suling Liu
author_facet Jiahui Xu
Xiaoli Yang
Qiaodan Deng
Cong Yang
Dong Wang
Guojuan Jiang
Xiaohong Yao
Xueyan He
Jiajun Ding
Jiankun Qiang
Juchuanli Tu
Rui zhang
Qun-Ying Lei
Zhi-min Shao
Xiuwu Bian
Ronggui Hu
Lixing Zhang
Suling Liu
author_sort Jiahui Xu
title TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
title_short TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
title_full TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
title_fullStr TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
title_full_unstemmed TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
title_sort tem8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4d5dff66ab924a66a148c3c003c9bdec
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