Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

Uremic pruritus is a distressful complication of chronic kidney disease and results in impaired quality of life and higher mortality rates. Intravenous sodium thiosulfate has been reported to alleviate pruritus in hemodialysis patients. We performed a systematic review and meta-analysis to estimate...

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Autores principales:	Ping-Hsun Lu, Hui-En Chuo, Ko-Lin Kuo, Jian-Fu Liao, Po-Hsuan Lu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	uremic pruritus sodium thiosulfate chronic kidney disease adverse drug reaction Medicine R
Acceso en línea:	https://doaj.org/article/4d665e2c5b4942bdbb029106bbfb4ef3
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spelling	oai:doaj.org-article:4d665e2c5b4942bdbb029106bbfb4ef32021-11-25T19:08:41ZClinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials10.3390/toxins131107692072-6651https://doaj.org/article/4d665e2c5b4942bdbb029106bbfb4ef32021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/769https://doaj.org/toc/2072-6651Uremic pruritus is a distressful complication of chronic kidney disease and results in impaired quality of life and higher mortality rates. Intravenous sodium thiosulfate has been reported to alleviate pruritus in hemodialysis patients. We performed a systematic review and meta-analysis to estimate the efficacy of intravenous sodium thiosulfate in patients with uremic pruritus. A systematic search of electronic databases up to June 2021 was conducted for randomized controlled trials that evaluated the clinical effects of sodium thiosulfate in the management of patients with uremic pruritus. Two reviewers selected eligible articles and evaluated the risk of bias; the results of pruritus assessment and uremic pruritus-related laboratory parameters in selected studies were analyzed. There are four trials published between 2018 and 2021, which include 222 participants. The sodium thiosulfate group displayed significant decrease in the pruritus score (standardized mean difference = −3.52, 95% confidence interval = −5.63 to −1.41, <i>p</i> = 0.001), without a significant increase in the adverse effects (risk ratio = 2.44, 95% confidence interval = 0.37 to 15.99, <i>p</i> = 0.35) compared to the control group. Administration of sodium thiosulfate is found to be a safe and efficacious complementary therapy in improving uremic pruritus in patients with chronic kidney disease.Ping-Hsun LuHui-En ChuoKo-Lin KuoJian-Fu LiaoPo-Hsuan LuMDPI AGarticleuremic pruritussodium thiosulfatechronic kidney diseaseadverse drug reactionMedicineRENToxins, Vol 13, Iss 769, p 769 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uremic pruritus sodium thiosulfate chronic kidney disease adverse drug reaction Medicine R
spellingShingle	uremic pruritus sodium thiosulfate chronic kidney disease adverse drug reaction Medicine R Ping-Hsun Lu Hui-En Chuo Ko-Lin Kuo Jian-Fu Liao Po-Hsuan Lu Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials
description	Uremic pruritus is a distressful complication of chronic kidney disease and results in impaired quality of life and higher mortality rates. Intravenous sodium thiosulfate has been reported to alleviate pruritus in hemodialysis patients. We performed a systematic review and meta-analysis to estimate the efficacy of intravenous sodium thiosulfate in patients with uremic pruritus. A systematic search of electronic databases up to June 2021 was conducted for randomized controlled trials that evaluated the clinical effects of sodium thiosulfate in the management of patients with uremic pruritus. Two reviewers selected eligible articles and evaluated the risk of bias; the results of pruritus assessment and uremic pruritus-related laboratory parameters in selected studies were analyzed. There are four trials published between 2018 and 2021, which include 222 participants. The sodium thiosulfate group displayed significant decrease in the pruritus score (standardized mean difference = −3.52, 95% confidence interval = −5.63 to −1.41, <i>p</i> = 0.001), without a significant increase in the adverse effects (risk ratio = 2.44, 95% confidence interval = 0.37 to 15.99, <i>p</i> = 0.35) compared to the control group. Administration of sodium thiosulfate is found to be a safe and efficacious complementary therapy in improving uremic pruritus in patients with chronic kidney disease.
format	article
author	Ping-Hsun Lu Hui-En Chuo Ko-Lin Kuo Jian-Fu Liao Po-Hsuan Lu
author_facet	Ping-Hsun Lu Hui-En Chuo Ko-Lin Kuo Jian-Fu Liao Po-Hsuan Lu
author_sort	Ping-Hsun Lu
title	Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials
title_short	Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials
title_full	Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials
title_fullStr	Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed	Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials
title_sort	clinical efficacy and safety of sodium thiosulfate in the treatment of uremic pruritus: a meta-analysis of randomized controlled trials
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4d665e2c5b4942bdbb029106bbfb4ef3
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Clinical Efficacy and Safety of Sodium Thiosulfate in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

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