Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome

Pandey, Bera, Shi et al. report the cryo-electron microscopy structure of the Rous sarcoma virus octameric intasome complex stabilized by a HIV-1 integrase strand transfer inhibitor. This new structure highlights the intrinsic flexibility of the distal integrase subunits and suggests that ordered co...

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Autores principales:	Krishan K. Pandey, Sibes Bera, Ke Shi, Michael J. Rau, Amarachi V. Oleru, James A. J. Fitzpatrick, Alan N. Engelman, Hideki Aihara, Duane P. Grandgenett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4d6bb66107444b65b39f3f0bed53819a
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spelling	oai:doaj.org-article:4d6bb66107444b65b39f3f0bed53819a2021-12-02T13:31:14ZCryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome10.1038/s42003-021-01855-22399-3642https://doaj.org/article/4d6bb66107444b65b39f3f0bed53819a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01855-2https://doaj.org/toc/2399-3642Pandey, Bera, Shi et al. report the cryo-electron microscopy structure of the Rous sarcoma virus octameric intasome complex stabilized by a HIV-1 integrase strand transfer inhibitor. This new structure highlights the intrinsic flexibility of the distal integrase subunits and suggests that ordered conformational transitions occur within the conserved intasome core during the assembly process.Krishan K. PandeySibes BeraKe ShiMichael J. RauAmarachi V. OleruJames A. J. FitzpatrickAlan N. EngelmanHideki AiharaDuane P. GrandgenettNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Krishan K. Pandey Sibes Bera Ke Shi Michael J. Rau Amarachi V. Oleru James A. J. Fitzpatrick Alan N. Engelman Hideki Aihara Duane P. Grandgenett Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome
description	Pandey, Bera, Shi et al. report the cryo-electron microscopy structure of the Rous sarcoma virus octameric intasome complex stabilized by a HIV-1 integrase strand transfer inhibitor. This new structure highlights the intrinsic flexibility of the distal integrase subunits and suggests that ordered conformational transitions occur within the conserved intasome core during the assembly process.
format	article
author	Krishan K. Pandey Sibes Bera Ke Shi Michael J. Rau Amarachi V. Oleru James A. J. Fitzpatrick Alan N. Engelman Hideki Aihara Duane P. Grandgenett
author_facet	Krishan K. Pandey Sibes Bera Ke Shi Michael J. Rau Amarachi V. Oleru James A. J. Fitzpatrick Alan N. Engelman Hideki Aihara Duane P. Grandgenett
author_sort	Krishan K. Pandey
title	Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome
title_short	Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome
title_full	Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome
title_fullStr	Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome
title_full_unstemmed	Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome
title_sort	cryo-em structure of the rous sarcoma virus octameric cleaved synaptic complex intasome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d6bb66107444b65b39f3f0bed53819a
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Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome

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