Alternative splicing and extensive RNA editing of human TPH2 transcripts.

Alternative splicing and extensive RNA editing of human TPH2 transcripts.

Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT. Recently, we discovered a second TPH isoform (TPH2) in verteb...

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Autores principales: Maik Grohmann, Paul Hammer, Maria Walther, Nils Paulmann, Andreas Büttner, Wolfgang Eisenmenger, Thomas C Baghai, Cornelius Schüle, Rainer Rupprecht, Michael Bader, Brigitta Bondy, Peter Zill, Josef Priller, Diego J Walther
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/4d71d04faf67483681cb1b2a68553f9f
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