Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis

Illouz et al vaccinated wildtype female mice against human Amyloid-β (Aβ) prior to them being bred with 5xFAD males, which model Aβ deposition, as occurs in Alzheimer’s Disease (AD) and Down’s syndrome (DS). The resultant offspring had reduced cortical Aβ levels and milder memory deficits, up to 4 m...

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Autores principales:	Tomer Illouz, Raneen Nicola, Linoy Ben-Shushan, Ravit Madar, Arya Biragyn, Eitan Okun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4d73926b773146d18ed0388b70fee444
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spelling	oai:doaj.org-article:4d73926b773146d18ed0388b70fee4442021-12-02T15:52:26ZMaternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis10.1038/s42003-021-01851-62399-3642https://doaj.org/article/4d73926b773146d18ed0388b70fee4442021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01851-6https://doaj.org/toc/2399-3642Illouz et al vaccinated wildtype female mice against human Amyloid-β (Aβ) prior to them being bred with 5xFAD males, which model Aβ deposition, as occurs in Alzheimer’s Disease (AD) and Down’s syndrome (DS). The resultant offspring had reduced cortical Aβ levels and milder memory deficits, up to 4 months after antibodies were no longer detectable, due to a long term shift in microglial phenotype. This study demonstrates that maternal immunization can alleviate cognitive decline and pathology associated with AD and DS.Tomer IllouzRaneen NicolaLinoy Ben-ShushanRavit MadarArya BiragynEitan OkunNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tomer Illouz Raneen Nicola Linoy Ben-Shushan Ravit Madar Arya Biragyn Eitan Okun Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
description	Illouz et al vaccinated wildtype female mice against human Amyloid-β (Aβ) prior to them being bred with 5xFAD males, which model Aβ deposition, as occurs in Alzheimer’s Disease (AD) and Down’s syndrome (DS). The resultant offspring had reduced cortical Aβ levels and milder memory deficits, up to 4 months after antibodies were no longer detectable, due to a long term shift in microglial phenotype. This study demonstrates that maternal immunization can alleviate cognitive decline and pathology associated with AD and DS.
format	article
author	Tomer Illouz Raneen Nicola Linoy Ben-Shushan Ravit Madar Arya Biragyn Eitan Okun
author_facet	Tomer Illouz Raneen Nicola Linoy Ben-Shushan Ravit Madar Arya Biragyn Eitan Okun
author_sort	Tomer Illouz
title	Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
title_short	Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
title_full	Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
title_fullStr	Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
title_full_unstemmed	Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
title_sort	maternal antibodies facilitate amyloid-β clearance by activating fc-receptor-syk-mediated phagocytosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d73926b773146d18ed0388b70fee444
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Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis

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