Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis
Illouz et al vaccinated wildtype female mice against human Amyloid-β (Aβ) prior to them being bred with 5xFAD males, which model Aβ deposition, as occurs in Alzheimer’s Disease (AD) and Down’s syndrome (DS). The resultant offspring had reduced cortical Aβ levels and milder memory deficits, up to 4 m...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/4d73926b773146d18ed0388b70fee444 |
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