Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.

<h4>Background</h4>Several genes implicated in high-density lipoprotein (HDL) metabolism have been reported to be associated with age-related macular degeneration (AMD). Furthermore, HDL transport the two carotenoids, lutein and zeaxanthin, which are highly suspected to play a key-role i...

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Autores principales:	Bénédicte M J Merle, Cécilia Maubaret, Jean-François Korobelnik, Marie-Noëlle Delyfer, Marie-Bénédicte Rougier, Jean-Charles Lambert, Philippe Amouyel, Florence Malet, Mélanie Le Goff, Jean-François Dartigues, Pascale Barberger-Gateau, Cécile Delcourt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d73a6d993e742af9c05842e12bf9153
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spelling	oai:doaj.org-article:4d73a6d993e742af9c05842e12bf91532021-11-18T08:48:03ZAssociation of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.1932-620310.1371/journal.pone.0079848https://doaj.org/article/4d73a6d993e742af9c05842e12bf91532013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223199/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Several genes implicated in high-density lipoprotein (HDL) metabolism have been reported to be associated with age-related macular degeneration (AMD). Furthermore, HDL transport the two carotenoids, lutein and zeaxanthin, which are highly suspected to play a key-role in the protection against AMD. The objective is to confirm the associations of HDL-related loci with AMD and to assess their associations with plasma lutein and zeaxanthin concentrations.<h4>Methods</h4>Alienor study is a prospective population-based study on nutrition and age-related eye diseases performed in 963 elderly residents of Bordeaux, France. AMD was graded according to the international classification, from non-mydriatic colour retinal photographs. Plasma lutein and zeaxanthin were determined by normal-phase high-performance liquid chromatography. The following polymorphisms were studied: rs493258 and rs10468017 (LIPC), rs3764261 (CETP), rs12678919 (LPL) and rs1883025 (ABCA1).<h4>Results</h4>After multivariate adjustment, the TT genotype of the LIPC rs493258 variant was significantly associated with a reduced risk for early and late AMD (OR=0.64, 95%CI: 0.41-0.99; p=0.049 and OR=0.26, 95%CI: 0.08-0.85; p=0.03, respectively), and with higher plasma zeaxanthin concentrations (p=0.03), while plasma lipids were not significantly different according to this SNP. Besides, the LPL variant was associated with early AMD (OR=0.67, 95%CI: 0.45-1.00; p=0.05) and both with plasma lipids and plasma lutein (p=0.047). Associations of LIPC rs10468017, CETP and ABCA1 polymorphisms with AMD did not reach statistical significance.<h4>Conclusion</h4>These findings suggest that LIPC and LPL genes could both modify the risk for AMD and the metabolism of lutein and zeaxanthin.Bénédicte M J MerleCécilia MaubaretJean-François KorobelnikMarie-Noëlle DelyferMarie-Bénédicte RougierJean-Charles LambertPhilippe AmouyelFlorence MaletMélanie Le GoffJean-François DartiguesPascale Barberger-GateauCécile DelcourtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79848 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bénédicte M J Merle Cécilia Maubaret Jean-François Korobelnik Marie-Noëlle Delyfer Marie-Bénédicte Rougier Jean-Charles Lambert Philippe Amouyel Florence Malet Mélanie Le Goff Jean-François Dartigues Pascale Barberger-Gateau Cécile Delcourt Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
description	<h4>Background</h4>Several genes implicated in high-density lipoprotein (HDL) metabolism have been reported to be associated with age-related macular degeneration (AMD). Furthermore, HDL transport the two carotenoids, lutein and zeaxanthin, which are highly suspected to play a key-role in the protection against AMD. The objective is to confirm the associations of HDL-related loci with AMD and to assess their associations with plasma lutein and zeaxanthin concentrations.<h4>Methods</h4>Alienor study is a prospective population-based study on nutrition and age-related eye diseases performed in 963 elderly residents of Bordeaux, France. AMD was graded according to the international classification, from non-mydriatic colour retinal photographs. Plasma lutein and zeaxanthin were determined by normal-phase high-performance liquid chromatography. The following polymorphisms were studied: rs493258 and rs10468017 (LIPC), rs3764261 (CETP), rs12678919 (LPL) and rs1883025 (ABCA1).<h4>Results</h4>After multivariate adjustment, the TT genotype of the LIPC rs493258 variant was significantly associated with a reduced risk for early and late AMD (OR=0.64, 95%CI: 0.41-0.99; p=0.049 and OR=0.26, 95%CI: 0.08-0.85; p=0.03, respectively), and with higher plasma zeaxanthin concentrations (p=0.03), while plasma lipids were not significantly different according to this SNP. Besides, the LPL variant was associated with early AMD (OR=0.67, 95%CI: 0.45-1.00; p=0.05) and both with plasma lipids and plasma lutein (p=0.047). Associations of LIPC rs10468017, CETP and ABCA1 polymorphisms with AMD did not reach statistical significance.<h4>Conclusion</h4>These findings suggest that LIPC and LPL genes could both modify the risk for AMD and the metabolism of lutein and zeaxanthin.
format	article
author	Bénédicte M J Merle Cécilia Maubaret Jean-François Korobelnik Marie-Noëlle Delyfer Marie-Bénédicte Rougier Jean-Charles Lambert Philippe Amouyel Florence Malet Mélanie Le Goff Jean-François Dartigues Pascale Barberger-Gateau Cécile Delcourt
author_facet	Bénédicte M J Merle Cécilia Maubaret Jean-François Korobelnik Marie-Noëlle Delyfer Marie-Bénédicte Rougier Jean-Charles Lambert Philippe Amouyel Florence Malet Mélanie Le Goff Jean-François Dartigues Pascale Barberger-Gateau Cécile Delcourt
author_sort	Bénédicte M J Merle
title	Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
title_short	Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
title_full	Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
title_fullStr	Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
title_full_unstemmed	Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
title_sort	association of hdl-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the alienor study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4d73a6d993e742af9c05842e12bf9153
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Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.

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