Homeostatic model of human thermoregulation with bi-stability

Abstract All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we intr...

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Autores principales:	Veronika Hajnová, Filip Zlámal, Peter Lenárt, Julie Bienertova-Vasku
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d760ba91dc045b3a7d11422f85cf95d
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spelling	oai:doaj.org-article:4d760ba91dc045b3a7d11422f85cf95d2021-12-02T19:09:31ZHomeostatic model of human thermoregulation with bi-stability10.1038/s41598-021-96280-02045-2322https://doaj.org/article/4d760ba91dc045b3a7d11422f85cf95d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96280-0https://doaj.org/toc/2045-2322Abstract All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.Veronika HajnováFilip ZlámalPeter LenártJulie Bienertova-VaskuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Veronika Hajnová Filip Zlámal Peter Lenárt Julie Bienertova-Vasku Homeostatic model of human thermoregulation with bi-stability
description	Abstract All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.
format	article
author	Veronika Hajnová Filip Zlámal Peter Lenárt Julie Bienertova-Vasku
author_facet	Veronika Hajnová Filip Zlámal Peter Lenárt Julie Bienertova-Vasku
author_sort	Veronika Hajnová
title	Homeostatic model of human thermoregulation with bi-stability
title_short	Homeostatic model of human thermoregulation with bi-stability
title_full	Homeostatic model of human thermoregulation with bi-stability
title_fullStr	Homeostatic model of human thermoregulation with bi-stability
title_full_unstemmed	Homeostatic model of human thermoregulation with bi-stability
title_sort	homeostatic model of human thermoregulation with bi-stability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d760ba91dc045b3a7d11422f85cf95d
work_keys_str_mv	AT veronikahajnova homeostaticmodelofhumanthermoregulationwithbistability AT filipzlamal homeostaticmodelofhumanthermoregulationwithbistability AT peterlenart homeostaticmodelofhumanthermoregulationwithbistability AT juliebienertovavasku homeostaticmodelofhumanthermoregulationwithbistability
_version_	1718377084833759232

Homeostatic model of human thermoregulation with bi-stability

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