NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE

Abstract. Streptococcus agalactiae can cause variety of diseases of newborns and adults. For successful colonization of different human tissues and organs as well as for suppression of the host immune system S. agalactiae expresses numerous virulence factors. For coordinated expression of the virule...

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Autores principales:	A. S. Rozhdestvenskaya, I. Santos-Sanches, A. V. Dmitriev
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	streptococcus agalactiae bgrrs two-component regulatory system protein bac virulence Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/4d7b2ff5ea1f4641aafa66c3081b929f
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spelling	oai:doaj.org-article:4d7b2ff5ea1f4641aafa66c3081b929f2021-11-22T07:09:46ZNATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE2220-76192313-739810.15789/2220-7619-2013-1-43-48https://doaj.org/article/4d7b2ff5ea1f4641aafa66c3081b929f2014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/122https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Streptococcus agalactiae can cause variety of diseases of newborns and adults. For successful colonization of different human tissues and organs as well as for suppression of the host immune system S. agalactiae expresses numerous virulence factors. For coordinated expression of the virulence genes S. agalactiae employs regulatory molecules including regulatory proteins of two-component systems. Results of the present study demonstrated that in S. agalactiae strain A49V the natural mutation in the brgR gene encoding for BgrR regulatory protein, which is component of regulatory system BgrRS, resulted in the repression of Bac protein synthesis, a virulence factor of S. agalactiae. A single nucleotide deletion in the bgrR gene has caused a shift of the reading frame and the changes in the primary, secondary and tertiary structures of the BgrR protein. The loss of functional activity of BgrR protein in A49V strain and repression of Bac protein synthesis have increased virulence of the strain in experimental animal streptococcal infection.A. S. RozhdestvenskayaI. Santos-SanchesA. V. DmitrievSankt-Peterburg : NIIÈM imeni Pasteraarticlestreptococcus agalactiaebgrrs two-component regulatory systemprotein bacvirulenceInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 3, Iss 1, Pp 43-48 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	streptococcus agalactiae bgrrs two-component regulatory system protein bac virulence Infectious and parasitic diseases RC109-216
spellingShingle	streptococcus agalactiae bgrrs two-component regulatory system protein bac virulence Infectious and parasitic diseases RC109-216 A. S. Rozhdestvenskaya I. Santos-Sanches A. V. Dmitriev NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE
description	Abstract. Streptococcus agalactiae can cause variety of diseases of newborns and adults. For successful colonization of different human tissues and organs as well as for suppression of the host immune system S. agalactiae expresses numerous virulence factors. For coordinated expression of the virulence genes S. agalactiae employs regulatory molecules including regulatory proteins of two-component systems. Results of the present study demonstrated that in S. agalactiae strain A49V the natural mutation in the brgR gene encoding for BgrR regulatory protein, which is component of regulatory system BgrRS, resulted in the repression of Bac protein synthesis, a virulence factor of S. agalactiae. A single nucleotide deletion in the bgrR gene has caused a shift of the reading frame and the changes in the primary, secondary and tertiary structures of the BgrR protein. The loss of functional activity of BgrR protein in A49V strain and repression of Bac protein synthesis have increased virulence of the strain in experimental animal streptococcal infection.
format	article
author	A. S. Rozhdestvenskaya I. Santos-Sanches A. V. Dmitriev
author_facet	A. S. Rozhdestvenskaya I. Santos-Sanches A. V. Dmitriev
author_sort	A. S. Rozhdestvenskaya
title	NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE
title_short	NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE
title_full	NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE
title_fullStr	NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE
title_full_unstemmed	NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE
title_sort	natural mutation in the gene of response regulator bgrr resulting in repression of bac protein synthesis, a pathogenicity factor of streptococcus agalactiae
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/4d7b2ff5ea1f4641aafa66c3081b929f
work_keys_str_mv	AT asrozhdestvenskaya naturalmutationinthegeneofresponseregulatorbgrrresultinginrepressionofbacproteinsynthesisapathogenicityfactorofstreptococcusagalactiae AT isantossanches naturalmutationinthegeneofresponseregulatorbgrrresultinginrepressionofbacproteinsynthesisapathogenicityfactorofstreptococcusagalactiae AT avdmitriev naturalmutationinthegeneofresponseregulatorbgrrresultinginrepressionofbacproteinsynthesisapathogenicityfactorofstreptococcusagalactiae
_version_	1718418039223877632

NATURAL MUTATION IN THE GENE OF RESPONSE REGULATOR BgrR RESULTING IN REPRESSION OF Bac PROTEIN SYNTHESIS, A PATHOGENICITY FACTOR OF STREPTOCOCCUS AGALACTIAE

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