FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer

FGF16 is implicated in the progression of some specific types of cancers, such as embryonic carcinoma, ovarian cancer, and liver cancer. Yet, the function of FGF16 in the development of lung cancer remains largely unexplored. In this study, we present the novel function of FGF16 and the regulation o...

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Autores principales:	He Wenfeng, Liu Xia, Luo Zhijie, Li Longmei, Fang Xisheng
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	fgf16 mir-520b growth lung cancer Medicine R
Acceso en línea:	https://doaj.org/article/4d7d5104fc1f49dc9781f0bb378ba2aa
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spelling	oai:doaj.org-article:4d7d5104fc1f49dc9781f0bb378ba2aa2021-12-05T14:10:54ZFGF16 regulated by miR-520b enhances the cell proliferation of lung cancer2391-546310.1515/med-2021-0232https://doaj.org/article/4d7d5104fc1f49dc9781f0bb378ba2aa2021-03-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0232https://doaj.org/toc/2391-5463FGF16 is implicated in the progression of some specific types of cancers, such as embryonic carcinoma, ovarian cancer, and liver cancer. Yet, the function of FGF16 in the development of lung cancer remains largely unexplored. In this study, we present the novel function of FGF16 and the regulation of miR-520b on FGF16 in lung cancer progression. In clinical lung cancer tissues, FGF16 is overexpressed and its high level is negatively associated with the low level of miR-520b. Furthermore, both the transcription and translation levels of FGF16 are restrained by miR-520b in lung cancer cells. For the regulatory mechanism investigation, miR-520b is able to directly bind to the 3′-untranslated region (3′UTR) of FGF16 mRNA, leading to its mRNA cleavage in the cells. Functionally, miR-520b reduces the growth of lung cancer and its inhibitor anti-miR520b is able to promote the growth through competing endogenous miR-520b. Moreover, FGF16 silence using RNA interference is capable of doing great damage to anti-miR-520b-accelerated growth of lung cancer. Thus, our finding indicates that FGF16 is a new target gene of miR-520b in lung cancer. For lung cancer, FGF16 may serve as a novel biomarker and miR-520b/FGF16 may be useful in clinical treatment.He WenfengLiu XiaLuo ZhijieLi LongmeiFang XishengDe Gruyterarticlefgf16mir-520bgrowthlung cancerMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 419-427 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fgf16 mir-520b growth lung cancer Medicine R
spellingShingle	fgf16 mir-520b growth lung cancer Medicine R He Wenfeng Liu Xia Luo Zhijie Li Longmei Fang Xisheng FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer
description	FGF16 is implicated in the progression of some specific types of cancers, such as embryonic carcinoma, ovarian cancer, and liver cancer. Yet, the function of FGF16 in the development of lung cancer remains largely unexplored. In this study, we present the novel function of FGF16 and the regulation of miR-520b on FGF16 in lung cancer progression. In clinical lung cancer tissues, FGF16 is overexpressed and its high level is negatively associated with the low level of miR-520b. Furthermore, both the transcription and translation levels of FGF16 are restrained by miR-520b in lung cancer cells. For the regulatory mechanism investigation, miR-520b is able to directly bind to the 3′-untranslated region (3′UTR) of FGF16 mRNA, leading to its mRNA cleavage in the cells. Functionally, miR-520b reduces the growth of lung cancer and its inhibitor anti-miR520b is able to promote the growth through competing endogenous miR-520b. Moreover, FGF16 silence using RNA interference is capable of doing great damage to anti-miR-520b-accelerated growth of lung cancer. Thus, our finding indicates that FGF16 is a new target gene of miR-520b in lung cancer. For lung cancer, FGF16 may serve as a novel biomarker and miR-520b/FGF16 may be useful in clinical treatment.
format	article
author	He Wenfeng Liu Xia Luo Zhijie Li Longmei Fang Xisheng
author_facet	He Wenfeng Liu Xia Luo Zhijie Li Longmei Fang Xisheng
author_sort	He Wenfeng
title	FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer
title_short	FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer
title_full	FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer
title_fullStr	FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer
title_full_unstemmed	FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer
title_sort	fgf16 regulated by mir-520b enhances the cell proliferation of lung cancer
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/4d7d5104fc1f49dc9781f0bb378ba2aa
work_keys_str_mv	AT hewenfeng fgf16regulatedbymir520benhancesthecellproliferationoflungcancer AT liuxia fgf16regulatedbymir520benhancesthecellproliferationoflungcancer AT luozhijie fgf16regulatedbymir520benhancesthecellproliferationoflungcancer AT lilongmei fgf16regulatedbymir520benhancesthecellproliferationoflungcancer AT fangxisheng fgf16regulatedbymir520benhancesthecellproliferationoflungcancer
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FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer

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