Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials

ABSTRACT: Background: Plasmodium falciparum gametocytaemia has been associated with anaemia. The aim of this review was to synthesize available evidence on the comparative effect of dihydroartemisinin-piperaquine (DHA-PQ) and artemether-lumefantrine (AL) on gametocyte clearance and haemoglobin reco...

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Autores principales:	Dawit Getachew Assefa, Gizachew Yismaw, Eyasu Makonnen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Dihydroartemisinin-piperaquine Artemether-lumefantrine Systematic review and meta-analysis Africa Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/4d7d908e20714ad082c74c7cf7d5e820
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spelling	oai:doaj.org-article:4d7d908e20714ad082c74c7cf7d5e8202021-11-04T04:26:53ZComparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials1201-971210.1016/j.ijid.2021.10.013https://doaj.org/article/4d7d908e20714ad082c74c7cf7d5e8202021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007992https://doaj.org/toc/1201-9712ABSTRACT: Background: Plasmodium falciparum gametocytaemia has been associated with anaemia. The aim of this review was to synthesize available evidence on the comparative effect of dihydroartemisinin-piperaquine (DHA-PQ) and artemether-lumefantrine (AL) on gametocyte clearance and haemoglobin recovery in children with uncomplicated P. falciparum malaria in Africa. Methods: A systematic literature search was undertaken to identify relevant articles from online databases. The search was performed from August 2020 to 30 April 2021. Extracted data from eligible studies were pooled as risk ratios with 95% confidence intervals (CI). Results: Gametocyte carriage was reduced in both treatment groups, with no significant difference found between the groups. However, on days 28 and 42, a significant increase in serum haemoglobin level from baseline was observed in the DHA-PQ group (standardized mean difference 0.15, 95% CI 0.05–0.26; participants=2715; studies=4; I2=32%, high quality of evidence) compared with the AL group (mean difference 0.35, 95% CI 0.12–0.59; participants=1434; studies=3; I2=35%, high quality of evidence). Conclusion: DHA-PQ had a greater impact on haemoglobin recovery than AL on days 28 and 42; this difference was significant.Dawit Getachew AssefaGizachew YismawEyasu MakonnenElsevierarticleDihydroartemisinin-piperaquineArtemether-lumefantrineSystematic review and meta-analysisAfricaInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 113, Iss , Pp 136-147 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dihydroartemisinin-piperaquine Artemether-lumefantrine Systematic review and meta-analysis Africa Infectious and parasitic diseases RC109-216
spellingShingle	Dihydroartemisinin-piperaquine Artemether-lumefantrine Systematic review and meta-analysis Africa Infectious and parasitic diseases RC109-216 Dawit Getachew Assefa Gizachew Yismaw Eyasu Makonnen Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials
description	ABSTRACT: Background: Plasmodium falciparum gametocytaemia has been associated with anaemia. The aim of this review was to synthesize available evidence on the comparative effect of dihydroartemisinin-piperaquine (DHA-PQ) and artemether-lumefantrine (AL) on gametocyte clearance and haemoglobin recovery in children with uncomplicated P. falciparum malaria in Africa. Methods: A systematic literature search was undertaken to identify relevant articles from online databases. The search was performed from August 2020 to 30 April 2021. Extracted data from eligible studies were pooled as risk ratios with 95% confidence intervals (CI). Results: Gametocyte carriage was reduced in both treatment groups, with no significant difference found between the groups. However, on days 28 and 42, a significant increase in serum haemoglobin level from baseline was observed in the DHA-PQ group (standardized mean difference 0.15, 95% CI 0.05–0.26; participants=2715; studies=4; I2=32%, high quality of evidence) compared with the AL group (mean difference 0.35, 95% CI 0.12–0.59; participants=1434; studies=3; I2=35%, high quality of evidence). Conclusion: DHA-PQ had a greater impact on haemoglobin recovery than AL on days 28 and 42; this difference was significant.
format	article
author	Dawit Getachew Assefa Gizachew Yismaw Eyasu Makonnen
author_facet	Dawit Getachew Assefa Gizachew Yismaw Eyasu Makonnen
author_sort	Dawit Getachew Assefa
title	Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials
title_short	Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials
title_full	Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials
title_fullStr	Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials
title_full_unstemmed	Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials
title_sort	comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated plasmodium falciparum malaria in africa: a systematic review and meta-analysis of randomized control trials
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4d7d908e20714ad082c74c7cf7d5e820
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Comparative effect of dihydroartemisinin-piperaquine and artemether-lumefantrine on gametocyte clearance and haemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials

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