Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging

Abstract Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-...

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Autores principales:	Qing Hu, Peipei Jiang, Yongjing Feng, Yan Xu, Nan Zhou, Weibo Chen, Li Zhu, Yali Hu, Zhengyang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d7f1141e1d14d6696721c4c4dcad73a
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spelling	oai:doaj.org-article:4d7f1141e1d14d6696721c4c4dcad73a2021-12-02T17:41:26ZNoninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging10.1038/s41598-021-92383-w2045-2322https://doaj.org/article/4d7f1141e1d14d6696721c4c4dcad73a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92383-whttps://doaj.org/toc/2045-2322Abstract Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient (D), pseudodiffusion coefficient (D) and vascular fraction (f) were evaluated. A multivariable model combing ADC, D, and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D, f values and ET (all p < 0.05). The multivariable model, ADC, D, f values and ET performed well in diagnosing endometrial fibrosis with AUC of 0.979, 0.965, 0.920, 0.901 and 0.833, respectively. The multivariable model revealed a better diagnostic accuracy than D, f and ET (all p < 0.05). Although ADC achieved a better diagnostic value than ET (z = 2.082, p < 0.05), no difference in AUC was shown among ADC, D, and f (all p > 0.05); between ET and D (p > 0.05); and between ET and f (p > 0.05). The reproducibility of ADC, D, f and D values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis.Qing HuPeipei JiangYongjing FengYan XuNan ZhouWeibo ChenLi ZhuYali HuZhengyang ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qing Hu Peipei Jiang Yongjing Feng Yan Xu Nan Zhou Weibo Chen Li Zhu Yali Hu Zhengyang Zhou Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
description	Abstract Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient (D), pseudodiffusion coefficient (D) and vascular fraction (f) were evaluated. A multivariable model combing ADC, D, and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D, f values and ET (all p < 0.05). The multivariable model, ADC, D, f values and ET performed well in diagnosing endometrial fibrosis with AUC of 0.979, 0.965, 0.920, 0.901 and 0.833, respectively. The multivariable model revealed a better diagnostic accuracy than D, f and ET (all p < 0.05). Although ADC achieved a better diagnostic value than ET (z = 2.082, p < 0.05), no difference in AUC was shown among ADC, D, and f (all p > 0.05); between ET and D (p > 0.05); and between ET and f (p > 0.05). The reproducibility of ADC, D, f and D values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis.
format	article
author	Qing Hu Peipei Jiang Yongjing Feng Yan Xu Nan Zhou Weibo Chen Li Zhu Yali Hu Zhengyang Zhou
author_facet	Qing Hu Peipei Jiang Yongjing Feng Yan Xu Nan Zhou Weibo Chen Li Zhu Yali Hu Zhengyang Zhou
author_sort	Qing Hu
title	Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_short	Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_full	Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_fullStr	Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_full_unstemmed	Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_sort	noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion mr imaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d7f1141e1d14d6696721c4c4dcad73a
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Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging

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