Joint effects of smoking and silicosis on diseases to the lungs.

Smokers are subject to being more susceptible to the long-term effects of silica dust, whilst it remains unclear whether the joint effect of smoking and silicosis differs amongst diseases to the lungs; this study aims to address this knowledge gap. This was a historical cohort study comprised of 320...

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Autores principales:	Lap Ah Tse, Ignatius T S Yu, Hong Qiu, Chi Chiu Leung
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d8028a9e5ac4c5ea7af89629afef97f
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spelling	oai:doaj.org-article:4d8028a9e5ac4c5ea7af89629afef97f2021-11-25T06:05:33ZJoint effects of smoking and silicosis on diseases to the lungs.1932-620310.1371/journal.pone.0104494https://doaj.org/article/4d8028a9e5ac4c5ea7af89629afef97f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25105409/?tool=EBIhttps://doaj.org/toc/1932-6203Smokers are subject to being more susceptible to the long-term effects of silica dust, whilst it remains unclear whether the joint effect of smoking and silicosis differs amongst diseases to the lungs; this study aims to address this knowledge gap. This was a historical cohort study comprised of 3202 silicotics in Hong Kong during 1981-2005 who were followed up till 31/12/2006. We estimated the standardized mortality ratio (SMR) in the smoking and never smoking silicotics using the mortality rates of male general population indiscriminately by smoking status, but these SMRs were regarded as biased. We adjusted these biased SMRs using "smoking adjustment factors (SAF)". We assessed the multiplicative interaction between smoking and silicosis using 'relative silicosis effect (RSE)' that was the ratio of SAF-corrected SMR of smoking silicotics to the never smokers. A RSE differs significantly from one implies the presence of multiplicative interaction. A significant excess SMR was observed for respiratory diseases (lung cancer, chronic obstructive pulmonary diseases [COPD], silicosis) and other diseases to the lungs (pulmonary heart disease, tuberculosis). All the 'biased-SMRs' in smokers were higher than those in never smokers, but the SAF-corrected SMRs became higher in never smokers. The RSE was 0.95 (95%CI: 0.37-3.55), 0.94 (95%CI: 0.42-2.60), and 0.81 (95%CI: 0.60-1.19) for lung cancer, COPD, and silicosis; whilst it was 1.21 (95%CI: 0.32-10.26) for tuberculosis and 1.02 (95%CI: 0.16-42.90) for pulmonary heart disease. This study firstly demonstrated the joint effect of smoking and silicosis may differ amongst diseases to the lungs, but power is limited.Lap Ah TseIgnatius T S YuHong QiuChi Chiu LeungPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104494 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lap Ah Tse Ignatius T S Yu Hong Qiu Chi Chiu Leung Joint effects of smoking and silicosis on diseases to the lungs.
description	Smokers are subject to being more susceptible to the long-term effects of silica dust, whilst it remains unclear whether the joint effect of smoking and silicosis differs amongst diseases to the lungs; this study aims to address this knowledge gap. This was a historical cohort study comprised of 3202 silicotics in Hong Kong during 1981-2005 who were followed up till 31/12/2006. We estimated the standardized mortality ratio (SMR) in the smoking and never smoking silicotics using the mortality rates of male general population indiscriminately by smoking status, but these SMRs were regarded as biased. We adjusted these biased SMRs using "smoking adjustment factors (SAF)". We assessed the multiplicative interaction between smoking and silicosis using 'relative silicosis effect (RSE)' that was the ratio of SAF-corrected SMR of smoking silicotics to the never smokers. A RSE differs significantly from one implies the presence of multiplicative interaction. A significant excess SMR was observed for respiratory diseases (lung cancer, chronic obstructive pulmonary diseases [COPD], silicosis) and other diseases to the lungs (pulmonary heart disease, tuberculosis). All the 'biased-SMRs' in smokers were higher than those in never smokers, but the SAF-corrected SMRs became higher in never smokers. The RSE was 0.95 (95%CI: 0.37-3.55), 0.94 (95%CI: 0.42-2.60), and 0.81 (95%CI: 0.60-1.19) for lung cancer, COPD, and silicosis; whilst it was 1.21 (95%CI: 0.32-10.26) for tuberculosis and 1.02 (95%CI: 0.16-42.90) for pulmonary heart disease. This study firstly demonstrated the joint effect of smoking and silicosis may differ amongst diseases to the lungs, but power is limited.
format	article
author	Lap Ah Tse Ignatius T S Yu Hong Qiu Chi Chiu Leung
author_facet	Lap Ah Tse Ignatius T S Yu Hong Qiu Chi Chiu Leung
author_sort	Lap Ah Tse
title	Joint effects of smoking and silicosis on diseases to the lungs.
title_short	Joint effects of smoking and silicosis on diseases to the lungs.
title_full	Joint effects of smoking and silicosis on diseases to the lungs.
title_fullStr	Joint effects of smoking and silicosis on diseases to the lungs.
title_full_unstemmed	Joint effects of smoking and silicosis on diseases to the lungs.
title_sort	joint effects of smoking and silicosis on diseases to the lungs.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4d8028a9e5ac4c5ea7af89629afef97f
work_keys_str_mv	AT lapahtse jointeffectsofsmokingandsilicosisondiseasestothelungs AT ignatiustsyu jointeffectsofsmokingandsilicosisondiseasestothelungs AT hongqiu jointeffectsofsmokingandsilicosisondiseasestothelungs AT chichiuleung jointeffectsofsmokingandsilicosisondiseasestothelungs
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Joint effects of smoking and silicosis on diseases to the lungs.

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