Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population

Hereditary mechanisms are partially responsible for individual differences in sensitivity to and the preference for sweet taste. The primary aim of this study was to examine the associations between 10 genetic variants and the intake of total sugar, added sugar, and sugars with sweet taste (i.e., mo...

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Autores principales:	Suzanne Janzi, Esther González-Padilla, Kevin Najafi, Stina Ramne, Emma Ahlqvist, Yan Borné, Emily Sonestedt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	genetic variants SNPs sugar intake total sugar added sugar sweet taste Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/4d82bad15ce54c899a14b1c7b97c41d2
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spelling	oai:doaj.org-article:4d82bad15ce54c899a14b1c7b97c41d22021-11-25T18:35:34ZSingle Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population10.3390/nu131139542072-6643https://doaj.org/article/4d82bad15ce54c899a14b1c7b97c41d22021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3954https://doaj.org/toc/2072-6643Hereditary mechanisms are partially responsible for individual differences in sensitivity to and the preference for sweet taste. The primary aim of this study was to examine the associations between 10 genetic variants and the intake of total sugar, added sugar, and sugars with sweet taste (i.e., monosaccharides and sucrose) in a middle-aged Swedish population. Two single nucleotide polymorphisms (SNPs) within the <i>Fibroblast grow factor 21 (FGF21)</i> gene, seven top hits from a genome-wide association study (GWAS) on total sugar intake, and one SNP within the fat mass and obesity associated (<i>FTO</i>) gene (the only SNP reaching GWAS significance in a previous study), were explored in relation to various forms of sugar intake in 22,794 individuals from the Malmö Diet and Cancer Study, a population-based cohort for which data were collected between 1991–1996. Significant associations (<i>p</i> = 6.82 × 10<sup>−7</sup> − 1.53 × 10<sup>−3</sup>) were observed between three SNPs (rs838145, rs838133, and rs8103840) in close relation to the <i>FGF21</i> gene with high Linkage Disequilibrium, and all the studied sugar intakes. For the rs11642841 within the <i>FTO</i> gene, associations were found exclusively among participants with a body mass index ≥ 25 (<i>p</i> < 5 × 10<sup>−3</sup>). None of the remaining SNPs studied were associated with sugar intake in our cohort. A further GWAS should be conducted to identify novel genetic variants associated with the intake of sugar.Suzanne JanziEsther González-PadillaKevin NajafiStina RamneEmma AhlqvistYan BornéEmily SonestedtMDPI AGarticlegenetic variantsSNPssugar intaketotal sugaradded sugarsweet tasteNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3954, p 3954 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genetic variants SNPs sugar intake total sugar added sugar sweet taste Nutrition. Foods and food supply TX341-641
spellingShingle	genetic variants SNPs sugar intake total sugar added sugar sweet taste Nutrition. Foods and food supply TX341-641 Suzanne Janzi Esther González-Padilla Kevin Najafi Stina Ramne Emma Ahlqvist Yan Borné Emily Sonestedt Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population
description	Hereditary mechanisms are partially responsible for individual differences in sensitivity to and the preference for sweet taste. The primary aim of this study was to examine the associations between 10 genetic variants and the intake of total sugar, added sugar, and sugars with sweet taste (i.e., monosaccharides and sucrose) in a middle-aged Swedish population. Two single nucleotide polymorphisms (SNPs) within the <i>Fibroblast grow factor 21 (FGF21)</i> gene, seven top hits from a genome-wide association study (GWAS) on total sugar intake, and one SNP within the fat mass and obesity associated (<i>FTO</i>) gene (the only SNP reaching GWAS significance in a previous study), were explored in relation to various forms of sugar intake in 22,794 individuals from the Malmö Diet and Cancer Study, a population-based cohort for which data were collected between 1991–1996. Significant associations (<i>p</i> = 6.82 × 10<sup>−7</sup> − 1.53 × 10<sup>−3</sup>) were observed between three SNPs (rs838145, rs838133, and rs8103840) in close relation to the <i>FGF21</i> gene with high Linkage Disequilibrium, and all the studied sugar intakes. For the rs11642841 within the <i>FTO</i> gene, associations were found exclusively among participants with a body mass index ≥ 25 (<i>p</i> < 5 × 10<sup>−3</sup>). None of the remaining SNPs studied were associated with sugar intake in our cohort. A further GWAS should be conducted to identify novel genetic variants associated with the intake of sugar.
format	article
author	Suzanne Janzi Esther González-Padilla Kevin Najafi Stina Ramne Emma Ahlqvist Yan Borné Emily Sonestedt
author_facet	Suzanne Janzi Esther González-Padilla Kevin Najafi Stina Ramne Emma Ahlqvist Yan Borné Emily Sonestedt
author_sort	Suzanne Janzi
title	Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population
title_short	Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population
title_full	Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population
title_fullStr	Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population
title_full_unstemmed	Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population
title_sort	single nucleotide polymorphisms in close proximity to the <i>fibroblast growth factor 21 (fgf21)</i> gene found to be associated with sugar intake in a swedish population
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4d82bad15ce54c899a14b1c7b97c41d2
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Single Nucleotide Polymorphisms in Close Proximity to the <i>Fibroblast Growth Factor 21 (FGF21)</i> Gene Found to Be Associated with Sugar Intake in a Swedish Population

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