Brachytherapy Approach Using 177Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β−-emitter 177Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (<s...

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Autores principales:	Min-Ying Lin, Hsin-Hua Hsieh, Jyh-Cheng Chen, Chuan-Lin Chen, Nin-Chu Sheu, Wen-Sheng Huang, Shinn-Ying Ho, Ting-Wen Chen, Yi-Jang Lee, Chun-Yi Wu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	brachytherapy <sup>177</sup>Lu-DTPA-pAuNS head and neck cancer photothermal therapy Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4d859694d2e94895830fab6fcac954dd
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spelling	oai:doaj.org-article:4d859694d2e94895830fab6fcac954dd2021-11-25T18:41:40ZBrachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model10.3390/pharmaceutics131119031999-4923https://doaj.org/article/4d859694d2e94895830fab6fcac954dd2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1903https://doaj.org/toc/1999-4923Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β<sup>−</sup>-emitter <sup>177</sup>Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (<sup>177</sup>Lu-DTPA-pAuNS) used in surface-enhanced Raman scattering and photothermal therapy (PTT). The accumulation and therapeutic efficacy of <sup>177</sup>Lu-DTPA-pAuNS were compared with those of <sup>177</sup>Lu-DTPA on an orthotopic HNSCC tumor model. The SPECT/CT imaging and biodistribution studies showed that <sup>177</sup>Lu-DTPA-pAuNS can be accumulated in the tumor up to 15 days, but <sup>177</sup>Lu-DTPA could not be detected at 24 h after injection. The tumor viability and growth were suppressed by injected <sup>177</sup>Lu-DTPA-pAuNS but not nonconjugated <sup>177</sup>Lu-DTPA, as evaluated by bioluminescent imaging. The radiation-absorbed dose of the normal organ was the highest in the liver (0.33 mSv/MBq) estimated in a 73 kg adult, but that of tumorsphere (0.5 g) was 3.55 mGy/MBq, while intravenous injection of <sup>177</sup>Lu-DTPA-pAuNS resulted in 1.97 mSv/MBq and 0.13 mGy/MBq for liver and tumorsphere, respectively. We also observed further enhancement of tumor-suppressive effects by a combination of <sup>177</sup>Lu-DTPA-pAuNS and PTT compared to <sup>177</sup>Lu-DTPA-pAuNS alone. In conclusion, <sup>1</sup><sup>77</sup>Lu-DTPA-pAuNS may be considered as a potential radiopharmaceutical agent for HNSCC brachytherapy.Min-Ying LinHsin-Hua HsiehJyh-Cheng ChenChuan-Lin ChenNin-Chu SheuWen-Sheng HuangShinn-Ying HoTing-Wen ChenYi-Jang LeeChun-Yi WuMDPI AGarticlebrachytherapy<sup>177</sup>Lu-DTPA-pAuNShead and neck cancerphotothermal therapyPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1903, p 1903 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brachytherapy <sup>177</sup>Lu-DTPA-pAuNS head and neck cancer photothermal therapy Pharmacy and materia medica RS1-441
spellingShingle	brachytherapy <sup>177</sup>Lu-DTPA-pAuNS head and neck cancer photothermal therapy Pharmacy and materia medica RS1-441 Min-Ying Lin Hsin-Hua Hsieh Jyh-Cheng Chen Chuan-Lin Chen Nin-Chu Sheu Wen-Sheng Huang Shinn-Ying Ho Ting-Wen Chen Yi-Jang Lee Chun-Yi Wu Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model
description	Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β<sup>−</sup>-emitter <sup>177</sup>Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (<sup>177</sup>Lu-DTPA-pAuNS) used in surface-enhanced Raman scattering and photothermal therapy (PTT). The accumulation and therapeutic efficacy of <sup>177</sup>Lu-DTPA-pAuNS were compared with those of <sup>177</sup>Lu-DTPA on an orthotopic HNSCC tumor model. The SPECT/CT imaging and biodistribution studies showed that <sup>177</sup>Lu-DTPA-pAuNS can be accumulated in the tumor up to 15 days, but <sup>177</sup>Lu-DTPA could not be detected at 24 h after injection. The tumor viability and growth were suppressed by injected <sup>177</sup>Lu-DTPA-pAuNS but not nonconjugated <sup>177</sup>Lu-DTPA, as evaluated by bioluminescent imaging. The radiation-absorbed dose of the normal organ was the highest in the liver (0.33 mSv/MBq) estimated in a 73 kg adult, but that of tumorsphere (0.5 g) was 3.55 mGy/MBq, while intravenous injection of <sup>177</sup>Lu-DTPA-pAuNS resulted in 1.97 mSv/MBq and 0.13 mGy/MBq for liver and tumorsphere, respectively. We also observed further enhancement of tumor-suppressive effects by a combination of <sup>177</sup>Lu-DTPA-pAuNS and PTT compared to <sup>177</sup>Lu-DTPA-pAuNS alone. In conclusion, <sup>1</sup><sup>77</sup>Lu-DTPA-pAuNS may be considered as a potential radiopharmaceutical agent for HNSCC brachytherapy.
format	article
author	Min-Ying Lin Hsin-Hua Hsieh Jyh-Cheng Chen Chuan-Lin Chen Nin-Chu Sheu Wen-Sheng Huang Shinn-Ying Ho Ting-Wen Chen Yi-Jang Lee Chun-Yi Wu
author_facet	Min-Ying Lin Hsin-Hua Hsieh Jyh-Cheng Chen Chuan-Lin Chen Nin-Chu Sheu Wen-Sheng Huang Shinn-Ying Ho Ting-Wen Chen Yi-Jang Lee Chun-Yi Wu
author_sort	Min-Ying Lin
title	Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model
title_short	Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model
title_full	Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model
title_fullStr	Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model
title_full_unstemmed	Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model
title_sort	brachytherapy approach using <sup>177</sup>lu conjugated gold nanostars and evaluation of biodistribution, tumor retention, dosimetry and therapeutic efficacy in head and neck tumor model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4d859694d2e94895830fab6fcac954dd
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Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

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