HIV-1 Escape from Small-Molecule Antagonism of Vif

ABSTRACT The HIV-1 accessory protein Vif, which counteracts the antiviral action of the DNA-editing cytidine deaminase APOBEC3G (A3G), is an attractive and yet unexploited therapeutic target. Vif reduces the virion incorporation of A3G by targeting the restriction factor for proteasomal degradation...

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Autores principales: Mark Sharkey, Natalia Sharova, Idrees Mohammed, Sarah E. Huff, Indrasena Reddy Kummetha, Gatikrushna Singh, Tariq M. Rana, Mario Stevenson
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
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Vif
Acceso en línea:https://doaj.org/article/4d8741ca218e4772905c111bd892ffb2
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