Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan

Fluid balance is an essential issue in critical care; however, the impact of early fluid balance on the long-term mortality in critically ill surgical patients remains unknown. This study aimed to address the impact of day 1–3 and day 4–7 fluid balance on the long-term mortality in critically ill su...

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Autores principales:	Chieh-Liang Wu, Kai-Chih Pai, Li-Ting Wong, Min-Shian Wang, Wen-Cheng Chao
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	critical illness surgical fluid balance mortality long-term outcome shock Medicine R
Acceso en línea:	https://doaj.org/article/4d8a83c9f84b4bd3be97ea766e792662
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spelling	oai:doaj.org-article:4d8a83c9f84b4bd3be97ea766e7926622021-11-11T17:31:58ZImpact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan10.3390/jcm102148732077-0383https://doaj.org/article/4d8a83c9f84b4bd3be97ea766e7926622021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4873https://doaj.org/toc/2077-0383Fluid balance is an essential issue in critical care; however, the impact of early fluid balance on the long-term mortality in critically ill surgical patients remains unknown. This study aimed to address the impact of day 1–3 and day 4–7 fluid balance on the long-term mortality in critically ill surgical patients. We enrolled patients who were admitted to surgical intensive care units (ICUs) during 2015–2019 at a tertiary hospital in central Taiwan and retrieved date-of-death from the Taiwanese nationwide death registration profile. We used a Log-rank test and a multivariable Cox proportional hazards regression model to determine the independent mortality impact of early fluid balance. A total of 6978 patients were included for analyses (mean age: 60.9 ± 15.9 years; 63.9% of them were men). In-hospital mortality, 90-day mortality, 1-year and overall mortality was 10.3%, 15.8%, 23.8% and 31.7%, respectively. In a multivariable Cox proportional hazard regression model adjusted for relevant covariates, we found that positive cumulative day 4–7 fluid balance was independently associated with long-term mortality (aHR 1.083, 95% CI 1.062–1.105), and a similar trend was found on day 1–3 fluid balance, although to a lesser extent (aHR 1.027, 95% CI 1.011–1.043). In conclusion, the fluid balance in the first week of ICU stay, particularly day 4–7 fluid balance, may affect the long-term outcome in critically ill surgical patients.Chieh-Liang WuKai-Chih PaiLi-Ting WongMin-Shian WangWen-Cheng ChaoMDPI AGarticlecritical illnesssurgicalfluid balancemortalitylong-term outcomeshockMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4873, p 4873 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	critical illness surgical fluid balance mortality long-term outcome shock Medicine R
spellingShingle	critical illness surgical fluid balance mortality long-term outcome shock Medicine R Chieh-Liang Wu Kai-Chih Pai Li-Ting Wong Min-Shian Wang Wen-Cheng Chao Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan
description	Fluid balance is an essential issue in critical care; however, the impact of early fluid balance on the long-term mortality in critically ill surgical patients remains unknown. This study aimed to address the impact of day 1–3 and day 4–7 fluid balance on the long-term mortality in critically ill surgical patients. We enrolled patients who were admitted to surgical intensive care units (ICUs) during 2015–2019 at a tertiary hospital in central Taiwan and retrieved date-of-death from the Taiwanese nationwide death registration profile. We used a Log-rank test and a multivariable Cox proportional hazards regression model to determine the independent mortality impact of early fluid balance. A total of 6978 patients were included for analyses (mean age: 60.9 ± 15.9 years; 63.9% of them were men). In-hospital mortality, 90-day mortality, 1-year and overall mortality was 10.3%, 15.8%, 23.8% and 31.7%, respectively. In a multivariable Cox proportional hazard regression model adjusted for relevant covariates, we found that positive cumulative day 4–7 fluid balance was independently associated with long-term mortality (aHR 1.083, 95% CI 1.062–1.105), and a similar trend was found on day 1–3 fluid balance, although to a lesser extent (aHR 1.027, 95% CI 1.011–1.043). In conclusion, the fluid balance in the first week of ICU stay, particularly day 4–7 fluid balance, may affect the long-term outcome in critically ill surgical patients.
format	article
author	Chieh-Liang Wu Kai-Chih Pai Li-Ting Wong Min-Shian Wang Wen-Cheng Chao
author_facet	Chieh-Liang Wu Kai-Chih Pai Li-Ting Wong Min-Shian Wang Wen-Cheng Chao
author_sort	Chieh-Liang Wu
title	Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan
title_short	Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan
title_full	Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan
title_fullStr	Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan
title_full_unstemmed	Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan
title_sort	impact of early fluid balance on long-term mortality in critically ill surgical patients: a retrospective cohort study in central taiwan
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4d8a83c9f84b4bd3be97ea766e792662
work_keys_str_mv	AT chiehliangwu impactofearlyfluidbalanceonlongtermmortalityincriticallyillsurgicalpatientsaretrospectivecohortstudyincentraltaiwan AT kaichihpai impactofearlyfluidbalanceonlongtermmortalityincriticallyillsurgicalpatientsaretrospectivecohortstudyincentraltaiwan AT litingwong impactofearlyfluidbalanceonlongtermmortalityincriticallyillsurgicalpatientsaretrospectivecohortstudyincentraltaiwan AT minshianwang impactofearlyfluidbalanceonlongtermmortalityincriticallyillsurgicalpatientsaretrospectivecohortstudyincentraltaiwan AT wenchengchao impactofearlyfluidbalanceonlongtermmortalityincriticallyillsurgicalpatientsaretrospectivecohortstudyincentraltaiwan
_version_	1718432061323214848

Impact of Early Fluid Balance on Long-Term Mortality in Critically Ill Surgical Patients: A Retrospective Cohort Study in Central Taiwan

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