Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Transglycosylases strengthen the fungal cell wall by forming a rigid network of crosslinks. Here, Fang et al. show that the five Crh transglycosylases of Aspergillus fumigatus are dispensable for cell wall integrity in vitro, and solve the crystal structure of Crh5 in complex with chitooligosacchari...

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Autores principales:	Wenxia Fang, Ana Belén Sanz, Sergio Galan Bartual, Bin Wang, Andrew T. Ferenbach, Vladimír Farkaš, Ramon Hurtado-Guerrero, Javier Arroyo, Daan M. F. van Aalten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d8d21ce0ca04436bd06a9ebe173e048
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spelling	oai:doaj.org-article:4d8d21ce0ca04436bd06a9ebe173e0482021-12-02T15:36:02ZMechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases10.1038/s41467-019-09674-02041-1723https://doaj.org/article/4d8d21ce0ca04436bd06a9ebe173e0482019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09674-0https://doaj.org/toc/2041-1723Transglycosylases strengthen the fungal cell wall by forming a rigid network of crosslinks. Here, Fang et al. show that the five Crh transglycosylases of Aspergillus fumigatus are dispensable for cell wall integrity in vitro, and solve the crystal structure of Crh5 in complex with chitooligosaccharides.Wenxia FangAna Belén SanzSergio Galan BartualBin WangAndrew T. FerenbachVladimír FarkašRamon Hurtado-GuerreroJavier ArroyoDaan M. F. van AaltenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenxia Fang Ana Belén Sanz Sergio Galan Bartual Bin Wang Andrew T. Ferenbach Vladimír Farkaš Ramon Hurtado-Guerrero Javier Arroyo Daan M. F. van Aalten Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
description	Transglycosylases strengthen the fungal cell wall by forming a rigid network of crosslinks. Here, Fang et al. show that the five Crh transglycosylases of Aspergillus fumigatus are dispensable for cell wall integrity in vitro, and solve the crystal structure of Crh5 in complex with chitooligosaccharides.
format	article
author	Wenxia Fang Ana Belén Sanz Sergio Galan Bartual Bin Wang Andrew T. Ferenbach Vladimír Farkaš Ramon Hurtado-Guerrero Javier Arroyo Daan M. F. van Aalten
author_facet	Wenxia Fang Ana Belén Sanz Sergio Galan Bartual Bin Wang Andrew T. Ferenbach Vladimír Farkaš Ramon Hurtado-Guerrero Javier Arroyo Daan M. F. van Aalten
author_sort	Wenxia Fang
title	Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
title_short	Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
title_full	Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
title_fullStr	Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
title_full_unstemmed	Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases
title_sort	mechanisms of redundancy and specificity of the aspergillus fumigatus crh transglycosylases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4d8d21ce0ca04436bd06a9ebe173e048
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Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

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