Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line...

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Autores principales:	Yifeng Xia, Xiaodong Ji, In Sock Jang, Christine Surka, Christy Hsu, Kai Wang, Mark Rolfe, Neil Bence, Gang Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4d8d29c70bdc4a77a7632fc27bcf2dfd
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spelling	oai:doaj.org-article:4d8d29c70bdc4a77a7632fc27bcf2dfd2021-12-02T16:10:32ZGenetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform10.1038/s42003-021-02352-22399-3642https://doaj.org/article/4d8d29c70bdc4a77a7632fc27bcf2dfd2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02352-2https://doaj.org/toc/2399-3642Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line barcoding.Yifeng XiaXiaodong JiIn Sock JangChristine SurkaChristy HsuKai WangMark RolfeNeil BenceGang LuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yifeng Xia Xiaodong Ji In Sock Jang Christine Surka Christy Hsu Kai Wang Mark Rolfe Neil Bence Gang Lu Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
description	Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line barcoding.
format	article
author	Yifeng Xia Xiaodong Ji In Sock Jang Christine Surka Christy Hsu Kai Wang Mark Rolfe Neil Bence Gang Lu
author_facet	Yifeng Xia Xiaodong Ji In Sock Jang Christine Surka Christy Hsu Kai Wang Mark Rolfe Neil Bence Gang Lu
author_sort	Yifeng Xia
title	Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
title_short	Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
title_full	Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
title_fullStr	Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
title_full_unstemmed	Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
title_sort	genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d8d29c70bdc4a77a7632fc27bcf2dfd
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Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

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