Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line...
Saved in:
| Main Authors: | Yifeng Xia, Xiaodong Ji, In Sock Jang, Christine Surka, Christy Hsu, Kai Wang, Mark Rolfe, Neil Bence, Gang Lu |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/4d8d29c70bdc4a77a7632fc27bcf2dfd |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Integrated genetic and pharmacologic interrogation of rare cancers
by: Andrew L. Hong, et al.
Published: (2016) -
Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
by: Sisi Chen, et al.
Published: (2016) -
A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines
by: Shengli Song, et al.
Published: (2021) -
A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function
by: Jeremy To, et al.
Published: (2021) -
Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells
by: Josh Tycko, et al.
Published: (2018)