IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission.

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Autores principales:	Yuko Tanabe, Yusuke Naito, Cristina Vasuta, Alfred Kihoon Lee, Youssouf Soumounou, Michael W. Linhoff, Hideto Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d91186d6dcd4afaac0d8d568c1932df
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spelling	oai:doaj.org-article:4d91186d6dcd4afaac0d8d568c1932df2021-12-02T14:40:32ZIgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α10.1038/s41467-017-00333-w2041-1723https://doaj.org/article/4d91186d6dcd4afaac0d8d568c1932df2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00333-whttps://doaj.org/toc/2041-1723Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission.Yuko TanabeYusuke NaitoCristina VasutaAlfred Kihoon LeeYoussouf SoumounouMichael W. LinhoffHideto TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuko Tanabe Yusuke Naito Cristina Vasuta Alfred Kihoon Lee Youssouf Soumounou Michael W. Linhoff Hideto Takahashi IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
description	Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission.
format	article
author	Yuko Tanabe Yusuke Naito Cristina Vasuta Alfred Kihoon Lee Youssouf Soumounou Michael W. Linhoff Hideto Takahashi
author_facet	Yuko Tanabe Yusuke Naito Cristina Vasuta Alfred Kihoon Lee Youssouf Soumounou Michael W. Linhoff Hideto Takahashi
author_sort	Yuko Tanabe
title	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_short	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_full	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_fullStr	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_full_unstemmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_sort	igsf21 promotes differentiation of inhibitory synapses via binding to neurexin2α
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4d91186d6dcd4afaac0d8d568c1932df
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IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

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