A scanning dynamic collimator for spot-scanning proton minibeam production

Abstract In proton minibeam radiation therapy, proton minibeams are typically produced by modulating a uniform field using a multislit collimator. Multislit collimators produce minibeams of fixed length and width, and a new collimator has to be manufactured each time a new minibeam array is required...

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Autores principales:	Marios Sotiropoulos, Yolanda Prezado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d95bda915b745758adc3897450e9b34
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spelling	oai:doaj.org-article:4d95bda915b745758adc3897450e9b342021-12-02T15:15:35ZA scanning dynamic collimator for spot-scanning proton minibeam production10.1038/s41598-021-97941-w2045-2322https://doaj.org/article/4d95bda915b745758adc3897450e9b342021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97941-whttps://doaj.org/toc/2045-2322Abstract In proton minibeam radiation therapy, proton minibeams are typically produced by modulating a uniform field using a multislit collimator. Multislit collimators produce minibeams of fixed length and width, and a new collimator has to be manufactured each time a new minibeam array is required, limiting its flexibility. In this work, we propose a scanning dynamic collimator for the generation of proton minibeams arrays. The new collimator system proposed is able to produce any minibeam required on an on-line basis by modulating the pencil beam spots of modern proton therapy machines, rather than a uniform field. The new collimator is evaluated through Monte Carlo simulations and the produced proton minibeams are compared with that of a multislit collimator. Furthermore, a proof of concept experiment is conducted to demonstrate the feasibility of producing a minibeam array by repositioning (i.e. scanning) a collimator. It is concluded that besides the technical challenges, the new collimator design is producing equivalent minibeam arrays to the multislit collimator, whilst is flexible to produce any minibeam array desired.Marios SotiropoulosYolanda PrezadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marios Sotiropoulos Yolanda Prezado A scanning dynamic collimator for spot-scanning proton minibeam production
description	Abstract In proton minibeam radiation therapy, proton minibeams are typically produced by modulating a uniform field using a multislit collimator. Multislit collimators produce minibeams of fixed length and width, and a new collimator has to be manufactured each time a new minibeam array is required, limiting its flexibility. In this work, we propose a scanning dynamic collimator for the generation of proton minibeams arrays. The new collimator system proposed is able to produce any minibeam required on an on-line basis by modulating the pencil beam spots of modern proton therapy machines, rather than a uniform field. The new collimator is evaluated through Monte Carlo simulations and the produced proton minibeams are compared with that of a multislit collimator. Furthermore, a proof of concept experiment is conducted to demonstrate the feasibility of producing a minibeam array by repositioning (i.e. scanning) a collimator. It is concluded that besides the technical challenges, the new collimator design is producing equivalent minibeam arrays to the multislit collimator, whilst is flexible to produce any minibeam array desired.
format	article
author	Marios Sotiropoulos Yolanda Prezado
author_facet	Marios Sotiropoulos Yolanda Prezado
author_sort	Marios Sotiropoulos
title	A scanning dynamic collimator for spot-scanning proton minibeam production
title_short	A scanning dynamic collimator for spot-scanning proton minibeam production
title_full	A scanning dynamic collimator for spot-scanning proton minibeam production
title_fullStr	A scanning dynamic collimator for spot-scanning proton minibeam production
title_full_unstemmed	A scanning dynamic collimator for spot-scanning proton minibeam production
title_sort	scanning dynamic collimator for spot-scanning proton minibeam production
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d95bda915b745758adc3897450e9b34
work_keys_str_mv	AT mariossotiropoulos ascanningdynamiccollimatorforspotscanningprotonminibeamproduction AT yolandaprezado ascanningdynamiccollimatorforspotscanningprotonminibeamproduction AT mariossotiropoulos scanningdynamiccollimatorforspotscanningprotonminibeamproduction AT yolandaprezado scanningdynamiccollimatorforspotscanningprotonminibeamproduction
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A scanning dynamic collimator for spot-scanning proton minibeam production

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