A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats

Abstract Muscle atrophy is one of the serious complications of chronic kidney disease (CKD). Dysregulation of mitochondrial quality control (MQC) process, including decrease mitochondrial biogenesis, impair mitochondrial dynamics and induce activation of mitophagy, play an important role in mediatin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dongtao Wang, Jianping Chen, Xinhui Liu, Ping Zheng, Gaofeng Song, Tiegang Yi, Shunmin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d9e668a07c34b20803e6ddf873d2d19
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4d9e668a07c34b20803e6ddf873d2d19
record_format	dspace
spelling	oai:doaj.org-article:4d9e668a07c34b20803e6ddf873d2d192021-12-02T16:06:18ZA Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats10.1038/s41598-017-10027-42045-2322https://doaj.org/article/4d9e668a07c34b20803e6ddf873d2d192017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10027-4https://doaj.org/toc/2045-2322Abstract Muscle atrophy is one of the serious complications of chronic kidney disease (CKD). Dysregulation of mitochondrial quality control (MQC) process, including decrease mitochondrial biogenesis, impair mitochondrial dynamics and induce activation of mitophagy, play an important role in mediating muscle wasting. This study aimed to observe effects of Jian-Pi-Yi-Shen (JPYS) decoction on muscle atrophy in CKD rats and explore its possible mechanism on regulation of MQC processes. The 5/6 nephrectomised rats were randomly allocated into 2 groups: CKD group and JPYS group. Besides, a sham-operated rats as sham group. All rats were treated for 6 weeks. Results showed that administration of JPYS decoction prevented body weight loss, muscle loss, muscle fiber size decrease, muscle protein degradation, and increased muscle protein systhesis. In addition, JPYS decoction increased the mitochondrial content and biogenesis proteins, and down-regulated the autophagy and mitophagy proteins. Furthermore, JPYS decoction increased mitochondrial fusion proteins, while decreased mitochondrial fission proteins. In conclusion, JPYS decoction increased mitochondrial content and biogenesis, restore the balance between fission and fusion, and inhibited autophagy-lysosome pathway (mitophagy). Collectively, our data showed that JPYS decoction to be beneficial to muscle atrophy in CKD, which might be associated with the modulation of MQC process.Dongtao WangJianping ChenXinhui LiuPing ZhengGaofeng SongTiegang YiShunmin LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dongtao Wang Jianping Chen Xinhui Liu Ping Zheng Gaofeng Song Tiegang Yi Shunmin Li A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats
description	Abstract Muscle atrophy is one of the serious complications of chronic kidney disease (CKD). Dysregulation of mitochondrial quality control (MQC) process, including decrease mitochondrial biogenesis, impair mitochondrial dynamics and induce activation of mitophagy, play an important role in mediating muscle wasting. This study aimed to observe effects of Jian-Pi-Yi-Shen (JPYS) decoction on muscle atrophy in CKD rats and explore its possible mechanism on regulation of MQC processes. The 5/6 nephrectomised rats were randomly allocated into 2 groups: CKD group and JPYS group. Besides, a sham-operated rats as sham group. All rats were treated for 6 weeks. Results showed that administration of JPYS decoction prevented body weight loss, muscle loss, muscle fiber size decrease, muscle protein degradation, and increased muscle protein systhesis. In addition, JPYS decoction increased the mitochondrial content and biogenesis proteins, and down-regulated the autophagy and mitophagy proteins. Furthermore, JPYS decoction increased mitochondrial fusion proteins, while decreased mitochondrial fission proteins. In conclusion, JPYS decoction increased mitochondrial content and biogenesis, restore the balance between fission and fusion, and inhibited autophagy-lysosome pathway (mitophagy). Collectively, our data showed that JPYS decoction to be beneficial to muscle atrophy in CKD, which might be associated with the modulation of MQC process.
format	article
author	Dongtao Wang Jianping Chen Xinhui Liu Ping Zheng Gaofeng Song Tiegang Yi Shunmin Li
author_facet	Dongtao Wang Jianping Chen Xinhui Liu Ping Zheng Gaofeng Song Tiegang Yi Shunmin Li
author_sort	Dongtao Wang
title	A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats
title_short	A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats
title_full	A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats
title_fullStr	A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats
title_full_unstemmed	A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats
title_sort	chinese herbal formula, jian-pi-yi-shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4d9e668a07c34b20803e6ddf873d2d19
work_keys_str_mv	AT dongtaowang achineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT jianpingchen achineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT xinhuiliu achineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT pingzheng achineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT gaofengsong achineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT tiegangyi achineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT shunminli achineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT dongtaowang chineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT jianpingchen chineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT xinhuiliu chineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT pingzheng chineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT gaofengsong chineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT tiegangyi chineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats AT shunminli chineseherbalformulajianpiyishendecoctionimprovesmuscleatrophyviaregulatingmitochondrialqualitycontrolprocessin56nephrectomisedrats
_version_	1718385021178347520

A Chinese herbal formula, Jian-Pi-Yi-Shen decoction, improves muscle atrophy via regulating mitochondrial quality control process in 5/6 nephrectomised rats

Ejemplares similares