Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.

In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Mult...

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Autores principales:	Michael Kraeussling, Toni Ulrich Wagner, Manfred Schartl
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d9eac0c8ccf4afe9140262af4369f85
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spelling	oai:doaj.org-article:4d9eac0c8ccf4afe9140262af4369f852021-11-18T06:50:38ZHighly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.1932-620310.1371/journal.pone.0021741https://doaj.org/article/4d9eac0c8ccf4afe9140262af4369f852011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21750728/?tool=EBIhttps://doaj.org/toc/1932-6203In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio.Michael KraeusslingToni Ulrich WagnerManfred SchartlPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21741 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Kraeussling Toni Ulrich Wagner Manfred Schartl Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
description	In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio.
format	article
author	Michael Kraeussling Toni Ulrich Wagner Manfred Schartl
author_facet	Michael Kraeussling Toni Ulrich Wagner Manfred Schartl
author_sort	Michael Kraeussling
title	Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
title_short	Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
title_full	Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
title_fullStr	Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
title_full_unstemmed	Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
title_sort	highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4d9eac0c8ccf4afe9140262af4369f85
work_keys_str_mv	AT michaelkraeussling highlyasynchronousandasymmetriccleavagedivisionsaccompanyearlytranscriptionalactivityinpreblastulamedakaembryos AT toniulrichwagner highlyasynchronousandasymmetriccleavagedivisionsaccompanyearlytranscriptionalactivityinpreblastulamedakaembryos AT manfredschartl highlyasynchronousandasymmetriccleavagedivisionsaccompanyearlytranscriptionalactivityinpreblastulamedakaembryos
_version_	1718424290948284416

Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos.

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