Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats

Abstract We studied the long-term effect of ileal transposition (IT) metabolic surgery on the hepatokines: retinol-binding protein-4 (RBP4), α-2-HS-glycoprotein (aHSG/fetuin-A), and fibroblast growth factor 21 (FGF21), C-reactive protein (CRP) plasma levels, glucose metabolism, body weight, liver hi...

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Autores principales:	Dominika Stygar, Tomasz Sawczyn, Agnieszka Dulska, Elżbieta Chełmecka, Łukasz Mielańczyk, Natalia Matysiak, Michał Kukla, Maciej Idzik, Jan Augustyniak, Andrzej Gabriel, Konrad Karcz, Jerzy Jochem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d9f648d136f41a38aaa8df7958dc697
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spelling	oai:doaj.org-article:4d9f648d136f41a38aaa8df7958dc6972021-12-02T14:15:53ZIleal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats10.1038/s41598-021-87293-w2045-2322https://doaj.org/article/4d9f648d136f41a38aaa8df7958dc6972021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87293-whttps://doaj.org/toc/2045-2322Abstract We studied the long-term effect of ileal transposition (IT) metabolic surgery on the hepatokines: retinol-binding protein-4 (RBP4), α-2-HS-glycoprotein (aHSG/fetuin-A), and fibroblast growth factor 21 (FGF21), C-reactive protein (CRP) plasma levels, glucose metabolism, body weight, liver histology, as well as total lipids concentration in muscle, liver, and fat tissue of obese Zucker (Crl:ZUC(ORL)-Leprfa) rats. 14 adult males were randomly submitted either to IT or SHAM (control) surgery. Pre-operative hepatokines plasma levels were not significantly different in rats submitted to IT or SHAM protocol. Three months after the procedures the plasma levels of RBP4, aHSG, FGF21, and CRP were significantly lower in IT-operated animals when compared to SHAM-operated group. Three and 12 weeks after the IT and SHAM surgery, the AUCOGTT were significantly lower than AUCOGTT before the surgery. HOMA-IR was lower in rats after IT surgery in comparison to the SHAM-operated rats. Muscle and liver total lipids concentration was reduced after the IT procedure when compared to pre-IT conditions. IT had a significant reductive impact on the body weight in comparison to SHAM surgery in the 4th, 6th, 8th, and 10th week after the surgery. We conclude that IT reduces hepatokines’ plasma concentrations, muscle and liver total lipids concentration but not the inflammatory processes in the liver of Zucker (Crl:ZUC(ORL)-Leprfa) rats.Dominika StygarTomasz SawczynAgnieszka DulskaElżbieta ChełmeckaŁukasz MielańczykNatalia MatysiakMichał KuklaMaciej IdzikJan AugustyniakAndrzej GabrielKonrad KarczJerzy JochemNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dominika Stygar Tomasz Sawczyn Agnieszka Dulska Elżbieta Chełmecka Łukasz Mielańczyk Natalia Matysiak Michał Kukla Maciej Idzik Jan Augustyniak Andrzej Gabriel Konrad Karcz Jerzy Jochem Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats
description	Abstract We studied the long-term effect of ileal transposition (IT) metabolic surgery on the hepatokines: retinol-binding protein-4 (RBP4), α-2-HS-glycoprotein (aHSG/fetuin-A), and fibroblast growth factor 21 (FGF21), C-reactive protein (CRP) plasma levels, glucose metabolism, body weight, liver histology, as well as total lipids concentration in muscle, liver, and fat tissue of obese Zucker (Crl:ZUC(ORL)-Leprfa) rats. 14 adult males were randomly submitted either to IT or SHAM (control) surgery. Pre-operative hepatokines plasma levels were not significantly different in rats submitted to IT or SHAM protocol. Three months after the procedures the plasma levels of RBP4, aHSG, FGF21, and CRP were significantly lower in IT-operated animals when compared to SHAM-operated group. Three and 12 weeks after the IT and SHAM surgery, the AUCOGTT were significantly lower than AUCOGTT before the surgery. HOMA-IR was lower in rats after IT surgery in comparison to the SHAM-operated rats. Muscle and liver total lipids concentration was reduced after the IT procedure when compared to pre-IT conditions. IT had a significant reductive impact on the body weight in comparison to SHAM surgery in the 4th, 6th, 8th, and 10th week after the surgery. We conclude that IT reduces hepatokines’ plasma concentrations, muscle and liver total lipids concentration but not the inflammatory processes in the liver of Zucker (Crl:ZUC(ORL)-Leprfa) rats.
format	article
author	Dominika Stygar Tomasz Sawczyn Agnieszka Dulska Elżbieta Chełmecka Łukasz Mielańczyk Natalia Matysiak Michał Kukla Maciej Idzik Jan Augustyniak Andrzej Gabriel Konrad Karcz Jerzy Jochem
author_facet	Dominika Stygar Tomasz Sawczyn Agnieszka Dulska Elżbieta Chełmecka Łukasz Mielańczyk Natalia Matysiak Michał Kukla Maciej Idzik Jan Augustyniak Andrzej Gabriel Konrad Karcz Jerzy Jochem
author_sort	Dominika Stygar
title	Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats
title_short	Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats
title_full	Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats
title_fullStr	Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats
title_full_unstemmed	Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats
title_sort	ileal transposition helps to regulate plasma hepatokine levels in obese zucker (crl:zuc(orl)-leprfa) rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d9f648d136f41a38aaa8df7958dc697
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Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats

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