Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study

Subsai Kongsaengdao,1,2 Benchalak Maneeton,3 Narong Maneeton3 1Division of Neurology, Department of Medicine, Rajvithi Hospital, Department of Medical Services, Public Health Ministry, Bangkok, Thailand; 2Department of Medicine, College of Medicine, Rangsit University, Bangkok, Thailand; 3Departmen...

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Autores principales:	Kongsaengdao S, Maneeton B, Maneeton N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Cervical dystonia botulinum toxin A the health related quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4da07d59e4604bb28601927cc98ec10e
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spelling	oai:doaj.org-article:4da07d59e4604bb28601927cc98ec10e2021-12-02T06:26:44ZQuality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study1178-2021https://doaj.org/article/4da07d59e4604bb28601927cc98ec10e2017-01-01T00:00:00Zhttps://www.dovepress.com/quality-of-life-in-cervical-dystonia-after-treatment-with-botulinum-to-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Subsai Kongsaengdao,1,2 Benchalak Maneeton,3 Narong Maneeton3 1Division of Neurology, Department of Medicine, Rajvithi Hospital, Department of Medical Services, Public Health Ministry, Bangkok, Thailand; 2Department of Medicine, College of Medicine, Rangsit University, Bangkok, Thailand; 3Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Thailand Objective: This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients.Materials and methods: A 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24). General HRQoL was assessed by using the Medical Outcomes’ 36-Item Short Form Health Survey (SF-36) and the EuroQoL 5-dimension questionnaire (EQ-5D). All the assessments were performed before and after the 24-week treatment period.Results: A total of 20 CD patients were enrolled in this study from April to December 2011. CDIP-58 and CDQ-24 scores, which assess disease-specific HRQoL, showed a significant improvement after 24 weeks of treatment by botulinum toxin A (P<0.001). However, EQ-5D and SF-36 scores, which assess general HRQoL, showed no significant improvement after the treatment (P>0.05).Conclusion: CD patients’ disease-specific HRQoL improved after being treated with multiple botulinum toxin A injections. However, general HRQoL was not improved. Keywords: cervical dystonia, botulinum toxin A, the health-related quality of life, 36-Item Short Form Health Survey, EuroQoL 5-dimension questionnaire, Cervical Dystonia Impact Profile-58 questionnaire, Craniocervical Dystonia Questionnaire-24Kongsaengdao SManeeton BManeeton NDove Medical PressarticleCervical dystoniabotulinum toxin Athe health related quality of lifeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 127-132 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical dystonia botulinum toxin A the health related quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Cervical dystonia botulinum toxin A the health related quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kongsaengdao S Maneeton B Maneeton N Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study
description	Subsai Kongsaengdao,1,2 Benchalak Maneeton,3 Narong Maneeton3 1Division of Neurology, Department of Medicine, Rajvithi Hospital, Department of Medical Services, Public Health Ministry, Bangkok, Thailand; 2Department of Medicine, College of Medicine, Rangsit University, Bangkok, Thailand; 3Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Thailand Objective: This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients.Materials and methods: A 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24). General HRQoL was assessed by using the Medical Outcomes’ 36-Item Short Form Health Survey (SF-36) and the EuroQoL 5-dimension questionnaire (EQ-5D). All the assessments were performed before and after the 24-week treatment period.Results: A total of 20 CD patients were enrolled in this study from April to December 2011. CDIP-58 and CDQ-24 scores, which assess disease-specific HRQoL, showed a significant improvement after 24 weeks of treatment by botulinum toxin A (P<0.001). However, EQ-5D and SF-36 scores, which assess general HRQoL, showed no significant improvement after the treatment (P>0.05).Conclusion: CD patients’ disease-specific HRQoL improved after being treated with multiple botulinum toxin A injections. However, general HRQoL was not improved. Keywords: cervical dystonia, botulinum toxin A, the health-related quality of life, 36-Item Short Form Health Survey, EuroQoL 5-dimension questionnaire, Cervical Dystonia Impact Profile-58 questionnaire, Craniocervical Dystonia Questionnaire-24
format	article
author	Kongsaengdao S Maneeton B Maneeton N
author_facet	Kongsaengdao S Maneeton B Maneeton N
author_sort	Kongsaengdao S
title	Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study
title_short	Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study
title_full	Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study
title_fullStr	Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study
title_full_unstemmed	Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study
title_sort	quality of life in cervical dystonia after treatment with botulinum toxin a: a 24-week prospective study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4da07d59e4604bb28601927cc98ec10e
work_keys_str_mv	AT kongsaengdaos qualityoflifeincervicaldystoniaaftertreatmentwithbotulinumtoxinaa24weekprospectivestudy AT maneetonb qualityoflifeincervicaldystoniaaftertreatmentwithbotulinumtoxinaa24weekprospectivestudy AT maneetonn qualityoflifeincervicaldystoniaaftertreatmentwithbotulinumtoxinaa24weekprospectivestudy
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Quality of life in cervical dystonia after treatment with botulinum toxin A: a 24-week prospective study

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