Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study

Background: The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate methods during the period in which latent/dormant cancer cells become more apparent. To investigate the appropriate sur...

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Autores principales:	Chonji Fukumoto, Ryo Oshima, Yuta Sawatani, Ryo Shiraishi, Toshiki Hyodo, Ryouta Kamimura, Tomonori Hasegawa, Yuske Komiyama, Sayaka Izumi, Atsushi Fujita, Takahiro Wakui, Hitoshi Kawamata
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oral squamous cell carcinoma surveillance recurrence metastasis positron emission tomography/computed tomography (FDG-PET/CT) contrast-enhanced computed tomography (CECT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4da3c54da4f94464b655713c6639c0e4
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spelling	oai:doaj.org-article:4da3c54da4f94464b655713c6639c0e42021-11-25T17:04:37ZSurveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study10.3390/cancers132258432072-6694https://doaj.org/article/4da3c54da4f94464b655713c6639c0e42021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5843https://doaj.org/toc/2072-6694Background: The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate methods during the period in which latent/dormant cancer cells become more apparent. To investigate the appropriate surveillance of patients with OSCC based on the individual risk for recurrence and/or metastasis, we performed a retrospective cohort study after the complete surgical resection of OSCC as the primary treatment. Methods: The study was performed in 324 patients with OSCC who had been primarily treated with surgery from 2007 to 2020 at our hospital. We investigated the period, timing, and methods (visual examination, palpation and imaging using FDG-PET/CT or CECT) for surveillance in each case that comprised postsurgical treatment. Results: Regarding the time to occurrence of postsurgical events, we found that half of cases of local recurrence, cervical lymph node metastasis, and distant metastasis occurred within 200 days, and 75% of all of these events occurred within 400 days. However, the mean time for second primary cancer was 1589 days. The postsurgical events were detected earlier by imaging examinations than they were by visual examination and palpation. Conclusions: For the surveillance of patients with OSCC after primary surgery, it is desirable to perform FDG-PET/CT within 3–6 months and at 1 year after surgery and to consider CECT as an option in between FDG-PET/CT, while continuing history and physical examinations for about 5 years based on individual risk assessment.Chonji FukumotoRyo OshimaYuta SawataniRyo ShiraishiToshiki HyodoRyouta KamimuraTomonori HasegawaYuske KomiyamaSayaka IzumiAtsushi FujitaTakahiro WakuiHitoshi KawamataMDPI AGarticleoral squamous cell carcinomasurveillancerecurrencemetastasispositron emission tomography/computed tomography (FDG-PET/CT)contrast-enhanced computed tomography (CECT)Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5843, p 5843 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral squamous cell carcinoma surveillance recurrence metastasis positron emission tomography/computed tomography (FDG-PET/CT) contrast-enhanced computed tomography (CECT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	oral squamous cell carcinoma surveillance recurrence metastasis positron emission tomography/computed tomography (FDG-PET/CT) contrast-enhanced computed tomography (CECT) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chonji Fukumoto Ryo Oshima Yuta Sawatani Ryo Shiraishi Toshiki Hyodo Ryouta Kamimura Tomonori Hasegawa Yuske Komiyama Sayaka Izumi Atsushi Fujita Takahiro Wakui Hitoshi Kawamata Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
description	Background: The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate methods during the period in which latent/dormant cancer cells become more apparent. To investigate the appropriate surveillance of patients with OSCC based on the individual risk for recurrence and/or metastasis, we performed a retrospective cohort study after the complete surgical resection of OSCC as the primary treatment. Methods: The study was performed in 324 patients with OSCC who had been primarily treated with surgery from 2007 to 2020 at our hospital. We investigated the period, timing, and methods (visual examination, palpation and imaging using FDG-PET/CT or CECT) for surveillance in each case that comprised postsurgical treatment. Results: Regarding the time to occurrence of postsurgical events, we found that half of cases of local recurrence, cervical lymph node metastasis, and distant metastasis occurred within 200 days, and 75% of all of these events occurred within 400 days. However, the mean time for second primary cancer was 1589 days. The postsurgical events were detected earlier by imaging examinations than they were by visual examination and palpation. Conclusions: For the surveillance of patients with OSCC after primary surgery, it is desirable to perform FDG-PET/CT within 3–6 months and at 1 year after surgery and to consider CECT as an option in between FDG-PET/CT, while continuing history and physical examinations for about 5 years based on individual risk assessment.
format	article
author	Chonji Fukumoto Ryo Oshima Yuta Sawatani Ryo Shiraishi Toshiki Hyodo Ryouta Kamimura Tomonori Hasegawa Yuske Komiyama Sayaka Izumi Atsushi Fujita Takahiro Wakui Hitoshi Kawamata
author_facet	Chonji Fukumoto Ryo Oshima Yuta Sawatani Ryo Shiraishi Toshiki Hyodo Ryouta Kamimura Tomonori Hasegawa Yuske Komiyama Sayaka Izumi Atsushi Fujita Takahiro Wakui Hitoshi Kawamata
author_sort	Chonji Fukumoto
title	Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_short	Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_full	Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_fullStr	Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_full_unstemmed	Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study
title_sort	surveillance for patients with oral squamous cell carcinoma after complete surgical resection as primary treatment: a single-center retrospective cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4da3c54da4f94464b655713c6639c0e4
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Surveillance for Patients with Oral Squamous Cell Carcinoma after Complete Surgical Resection as Primary Treatment: A Single-Center Retrospective Cohort Study

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