Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

Abstract Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the ribosome rescue process of trans-translation in Mycobacterium tuberculosis. This model sug...

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Autores principales: Nicholas A. Dillon, Nicholas D. Peterson, Heather A. Feaga, Kenneth C. Keiler, Anthony D. Baughn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4da58e057f364be4a086d7bff82b17a5
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