The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children.
Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pe...
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oai:doaj.org-article:4da61d453c364203b6d743bfdeafaafe2021-11-18T08:59:01ZThe clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children.1932-620310.1371/journal.pone.0072141https://doaj.org/article/4da61d453c364203b6d743bfdeafaafe2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977232/?tool=EBIhttps://doaj.org/toc/1932-6203Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1-4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I-related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti-MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes.Marc AnsariChakradhara Rao S UppugunduriSylvie Ferrari-LacrazHenrique BittencourtFabienne Gumy-PauseYves ChalandonJean-Marie TiercyTal SchechterAdam GassasJohn D DoyleLee DupuisMichel DuvalMaja KrajinovicJean VillardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e72141 (2013) |
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Medicine R Science Q Marc Ansari Chakradhara Rao S Uppugunduri Sylvie Ferrari-Lacraz Henrique Bittencourt Fabienne Gumy-Pause Yves Chalandon Jean-Marie Tiercy Tal Schechter Adam Gassas John D Doyle Lee Dupuis Michel Duval Maja Krajinovic Jean Villard The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. |
| description |
Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1-4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I-related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti-MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes. |
| format |
article |
| author |
Marc Ansari Chakradhara Rao S Uppugunduri Sylvie Ferrari-Lacraz Henrique Bittencourt Fabienne Gumy-Pause Yves Chalandon Jean-Marie Tiercy Tal Schechter Adam Gassas John D Doyle Lee Dupuis Michel Duval Maja Krajinovic Jean Villard |
| author_facet |
Marc Ansari Chakradhara Rao S Uppugunduri Sylvie Ferrari-Lacraz Henrique Bittencourt Fabienne Gumy-Pause Yves Chalandon Jean-Marie Tiercy Tal Schechter Adam Gassas John D Doyle Lee Dupuis Michel Duval Maja Krajinovic Jean Villard |
| author_sort |
Marc Ansari |
| title |
The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. |
| title_short |
The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. |
| title_full |
The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. |
| title_fullStr |
The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. |
| title_full_unstemmed |
The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children. |
| title_sort |
clinical relevance of pre-formed anti-hla and anti-mica antibodies after cord blood transplantation in children. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/4da61d453c364203b6d743bfdeafaafe |
| work_keys_str_mv |
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| _version_ |
1718421080803115008 |