Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy

Anna Tani,1 Toshiyuki Yasui,2 Sumika Matsui,1 Takeshi Kato,1 Naoko Tsuchiya,3 Mitsutoshi Yuzurihara,3 Yoshio Kase,3 Minoru Irahara11Department of Obstetrics and Gynecology, 2Department of Reproductive Technology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushim...

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Autores principales:	Tani A, Yasui T, Matsui S, Kato T, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4da8435c03594bb3bfb89b3b45c62fcf
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spelling	oai:doaj.org-article:4da8435c03594bb3bfb89b3b45c62fcf2021-12-02T01:51:46ZCirculating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy1178-7031https://doaj.org/article/4da8435c03594bb3bfb89b3b45c62fcf2013-12-01T00:00:00Zhttp://www.dovepress.com/circulating-levels-of-monocyte-chemoattractant-protein-1-and-interleuk-a15401https://doaj.org/toc/1178-7031 Anna Tani,1 Toshiyuki Yasui,2 Sumika Matsui,1 Takeshi Kato,1 Naoko Tsuchiya,3 Mitsutoshi Yuzurihara,3 Yoshio Kase,3 Minoru Irahara11Department of Obstetrics and Gynecology, 2Department of Reproductive Technology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan; 3Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, JapanPurpose: The aim of the study reported here was to determine the effect of surgical menopause by bilateral salpingo-oophorectomy (BSO) on circulating levels of cytokines and chemokines related to the pathogenesis of atherosclerosis.Patients and methods: A total of 110 women were recruited for this study from the outpatient clinic of our facility. We divided the women into three groups: 1) women with a regular menstrual cycle, 2) women in whom less than 5 years had passed since their BSO, and 3) women in whom 5 years or more had passed since their BSO. Concentrations of nine cytokines and chemokines in serum were measured.Results: The serum monocyte chemoattractant protein-1 (MCP-1) level in women in whom less than 5 years had passed since their BSO was significantly higher than in women with a regular menstrual cycle (P<0.05). There were significant differences in serum interleukin (IL)-7 among the three groups (P=0.035). MCP-1 showed a significant positive correlation (r=0.320, P=0.008) with follicle-stimulating hormone in women with a regular menstrual cycle and in women in whom less than 5 years had passed since their BSO.Conclusion: A hypoestrogenic state due to BSO induced changes in MCP-1 and IL-7 levels. MCP-1 level showed a significant increase in the early period after BSO, while IL-7 level showed a significant decrease in the late period after BSO.Keywords: follicle-stimulating hormone, cytokines, chemokines, hypoestrogenism, surgical menopauseTani AYasui TMatsui SKato TTsuchiya NYuzurihara MKase YIrahara MDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2014, Iss default, Pp 1-7 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Tani A Yasui T Matsui S Kato T Tsuchiya N Yuzurihara M Kase Y Irahara M Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy
description	Anna Tani,1 Toshiyuki Yasui,2 Sumika Matsui,1 Takeshi Kato,1 Naoko Tsuchiya,3 Mitsutoshi Yuzurihara,3 Yoshio Kase,3 Minoru Irahara11Department of Obstetrics and Gynecology, 2Department of Reproductive Technology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan; 3Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, JapanPurpose: The aim of the study reported here was to determine the effect of surgical menopause by bilateral salpingo-oophorectomy (BSO) on circulating levels of cytokines and chemokines related to the pathogenesis of atherosclerosis.Patients and methods: A total of 110 women were recruited for this study from the outpatient clinic of our facility. We divided the women into three groups: 1) women with a regular menstrual cycle, 2) women in whom less than 5 years had passed since their BSO, and 3) women in whom 5 years or more had passed since their BSO. Concentrations of nine cytokines and chemokines in serum were measured.Results: The serum monocyte chemoattractant protein-1 (MCP-1) level in women in whom less than 5 years had passed since their BSO was significantly higher than in women with a regular menstrual cycle (P<0.05). There were significant differences in serum interleukin (IL)-7 among the three groups (P=0.035). MCP-1 showed a significant positive correlation (r=0.320, P=0.008) with follicle-stimulating hormone in women with a regular menstrual cycle and in women in whom less than 5 years had passed since their BSO.Conclusion: A hypoestrogenic state due to BSO induced changes in MCP-1 and IL-7 levels. MCP-1 level showed a significant increase in the early period after BSO, while IL-7 level showed a significant decrease in the late period after BSO.Keywords: follicle-stimulating hormone, cytokines, chemokines, hypoestrogenism, surgical menopause
format	article
author	Tani A Yasui T Matsui S Kato T Tsuchiya N Yuzurihara M Kase Y Irahara M
author_facet	Tani A Yasui T Matsui S Kato T Tsuchiya N Yuzurihara M Kase Y Irahara M
author_sort	Tani A
title	Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy
title_short	Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy
title_full	Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy
title_fullStr	Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy
title_full_unstemmed	Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy
title_sort	circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/4da8435c03594bb3bfb89b3b45c62fcf
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Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy

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