Dexmedetomidine Alleviates LPS-Induced Neuronal Dysfunction by Modulating the AKT/GSK-3β/CRMP-2 Pathway in Hippocampal Neurons

QR Code

Dexmedetomidine Alleviates LPS-Induced Neuronal Dysfunction by Modulating the AKT/GSK-3β/CRMP-2 Pathway in Hippocampal Neurons

Wei Zeng,1,2 Chunyuan Zhang,2 Qingshan Long,3 Yalan Li1 1Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong, People’s Republic of China; 2Department of Anesthesiology, Affiliated Boai Hospital of Zhongshan, Southern Medical Univers...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Zeng W, Zhang C, Long Q, Li Y
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2021
Sujets:	dexmedetomidine postoperative cognitive dysfunction neurological impairment akt gsk-3β crmp-2 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Accès en ligne:	https://doaj.org/article/4dac92969a2e4e40b90a9571a7b8ffeb
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway
par: He H, et autres
Publié: (2019)

Gadolinium-doped bioglass scaffolds promote osteogenic differentiation of hBMSC via the Akt/GSK3β pathway and facilitate bone repair in vivo
par: Zhu DY, et autres
Publié: (2019)

Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer
par: Cuixiang Xu, et autres
Publié: (2021)

Feasibility of low-dose dexmedetomidine for prevention of postoperative delirium after intracranial operations: a pilot randomized controlled trial
par: Xuan He, et autres
Publié: (2021)

Effect of dexmedetomidine on hippocampal neuron development and BDNF-TrkB signal expression in neonatal rats
par: Lv J, et autres
Publié: (2016)

ROLE OF GSK-3 IN Wnt/β-CATENIN SIGNALING PATHWAY IN OBESITY
par: A. S. Kulakova, et autres
Publié: (2021)

Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington’s Disease
par: Tatiana Brustovetsky, et autres
Publié: (2021)

Dexmedetomidine may decrease the bupivacaine toxicity to heart
par: Jin Zhousheng, et autres
Publié: (2021)

DEXMEDETOMIDINE FOR ACUTE POSTOPERATIVE ANALGESIA IN PATIENTS UNDERGOING LAPAROTOMY
par: Liaquat Ali, et autres
Publié: (2019)

Improving the anti-keloid outcomes through liposomes loading paclitaxel–cholesterol complexes
par: Wang MJ, et autres
Publié: (2019)

A comparative study of caudal anesthesia with bupivacaine v/s bupivacaine with dexmedetomidine in lower abdominal surgeries in pediatric age group
par: Kishore Kumar N., et autres
Publié: (2021)

Essential meiotic structure-specific endonuclease1 (EME1) promotes malignant features in gastric cancer cells via the Akt/GSK3B/CCND1 pathway
par: Zhiguo Guo, et autres
Publié: (2021)

Dexmedetomidine vs. lidocaine for postoperative analgesia in pediatric patients undergoing craniotomy: a protocol for a prospective, randomized, double-blinded, placebo-controlled trial
par: Yuan Zhang, et autres
Publié: (2021)

Effects of dexmedetomidine and clonidine as propofol adjuvants on intra-operative hemodynamics and recovery profiles in patients undergoing laparoscopic cholecystectomy: A prospective randomized comparative study
par: Naz Anjum, et autres
Publié: (2015)

GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity
par: Sun Q, et autres
Publié: (2019)

Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3β/Nrf2
par: Yuan-Ye Dang, et autres
Publié: (2021)

FSC231 alleviates paclitaxel‐induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK‐3β and ERK1/2
par: Xi Zhang, et autres
Publié: (2021)

Lemur tyrosine kinase 2 silencing inhibits the proliferation of gastric cancer cells by regulating GSK-3β phosphorylation and β-catenin nuclear translocation
par: Xin Han, et autres
Publié: (2021)

β-Hydroxybutyrate Mitigated Heart Failure with Preserved Ejection Fraction by Increasing Treg Cells via Nox2/GSK-3β
par: Liao S, et autres
Publié: (2021)

Cerebroprotein Hydrolysate-I Inhibits Hippocampal Neuronal Apoptosis by Activating PI3K/Akt Signaling Pathway in Vascular Dementia Mice
par: Wu X, et autres
Publié: (2021)

The Effect Of Intraoperative Use Of Dexmedetomidine During The Daytime Operation Vs The Nighttime Operation On Postoperative Sleep Quality And Pain Under General Anesthesia
par: Song B, et autres
Publié: (2019)

The Effects of Intraoperative Dexmedetomidine Use and Its Different Dose on Postoperative Sleep Disturbance in Patients Who Have Undergone Non-Cardiac Major Surgery: A Real-World Cohort Study
par: Duan G, et autres
Publié: (2020)

Dexmedetomidine attenuates the propofol-induced long-term neurotoxicity in the developing brain of rats by enhancing the PI3K/Akt signaling pathway
par: Xiao Y, et autres
Publié: (2018)

Melatonin alleviates hippocampal GR inhibition and depression-like behavior induced by constant light exposure in mice
par: Yang Yang, et autres
Publié: (2021)

Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis
par: Junhua Wang, et autres
Publié: (2021)

Dexmedetomidine for the management of postictal agitation after electroconvulsive therapy with S-ketamine anesthesia
par: Aksay SS, et autres
Publié: (2017)

Mechanical Stretching-Induced Traumatic Brain Injury Is Mediated by the Formation of GSK-3β-Tau Complex to Impair Insulin Signaling Transduction
par: Pei-Wen Cheng, et autres
Publié: (2021)

Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats
par: Haiyan Yang, et autres
Publié: (2019)

LncRNA MEG3 Reduces Hippocampal Neuron Apoptosis via the PI3K/AKT/mTOR Pathway in a Rat Model of Temporal Lobe Epilepsy
par: Zhang H, et autres
Publié: (2020)

The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders
par: Wang X, et autres
Publié: (2021)

Knockdown of lncRNA TUG1 inhibits hippocampal neuronal apoptosis and participates in aerobic exercise-alleviated vascular cognitive impairment
par: Wang,Jing, et autres
Publié: (2020)

GSK-3 protein and the heart: friend or foe?
par: B. Huisamen, et autres
Publié: (2017)

Bradycardia resulting in cardiac arrest in a critically ill patient receiving dexmedetomidine
par: Anoosh Bahraini, et autres
Publié: (2021)

Dexmedetomidine versus Propofol Sedation for Prevention of Postoperative Delirium: Clarifications Required [Letter]
par: Deng J, et autres
Publié: (2021)

Experience of Dexmedetomidine using for intraoperative analgosedation during ophthalmic operations
par: Maxim Khodakovsky
Publié: (2021)

Attenuative Effects of Fluoxetine and <i>Triticum aestivum</i> against Aluminum-Induced Alzheimer’s Disease in Rats: The Possible Consequences on Hepatotoxicity and Nephrotoxicity
par: Karema Abu-Elfotuh, et autres
Publié: (2021)

Exogenous Plant gma-miR-159a, Identified by miRNA Library Functional Screening, Ameliorated Hepatic Stellate Cell Activation and Inflammation via Inhibiting GSK-3β-Mediated Pathways
par: Yu WY, et autres
Publié: (2021)

Protective effect and mechanism of dexmedetomidine on lung injury in diabetic mice with myocardial ischemia reperfusion
par: Ai-Mei Li, et autres
Publié: (2021)

Analysis of dexmedetomidine on the quality of awakening during neurosurgery
par: Cao Jing, et autres
Publié: (2019)

Ketamine versus Dexmedetomidine in Local Wound Infiltration for Postoperative Pain Relief in Cesarean Section
par: Nourhan R. Biomy, et autres
Publié: (2021)