IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN

Recent epidemiological events showed that pregnant women are the most vulnerable part of population if there is the flu in the country and they die much more often than the rest part of people. That is why influenza vaccination of population including pregnant women is one of the priorities of publi...

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Autores principales:	M. P. Kostinov, A. P. Cherdantsev, A. D. Shmitko, D. A. Praulova, A. D. Protasov, U. A. Dagil, T. A. Kostinova, N. K. Akhmatova, E. A. Chromova, A. A. Ryzhov, D. A. Blagovidov, V. B. Polishchuk, O. O. Magarshak, E. S. Korovkina
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2017
Materias:	influenza immunoadjuvant vaccines vaccination of pregnant women subunit trivalent immunoadjuvant vaccine postvaccinal immune response Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/4db111c8f3844735b1f77704bb4d194f
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spelling	oai:doaj.org-article:4db111c8f3844735b1f77704bb4d194f2021-11-22T07:09:48ZIMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN2220-76192313-739810.15789/2220-7619-2017-2-193-202https://doaj.org/article/4db111c8f3844735b1f77704bb4d194f2017-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/519https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Recent epidemiological events showed that pregnant women are the most vulnerable part of population if there is the flu in the country and they die much more often than the rest part of people. That is why influenza vaccination of population including pregnant women is one of the priorities of public health service in our state. Worldwide experience of influenza vaccination of either adults or children by new adjuvant vaccine has caused our research of its efficiency among pregnant women. The aim of the study was to investigate the level of antibodies to influenza virus strain A/H1N1/v, A/H3N2 and B in pregnant women vaccinated adjuvant trivalent subunit vaccine. Our research is randomized and comparative on parallel groups. It was carried out within the demands of Russian Federation and International ethic norms adapted to such kind of researches. Evaluation of the immunogenicity of the vaccine was conducted in 27 pregnant women in the II trimester of gestation, and in 23 pregnant women in the III trimester of gestation, 19 non-pregnant women was in the control group. The level of antibodies in the serum was determined using a reaction of hemagglutination inhibition before and 1, 3, 6, 9 and 12 months after the vaccination. Revealed that influenza vaccination of pregnant women in the II and III trimester, causes the increase in titers of antibodies to vaccine influenza strains A and B, to fully meet the required criteria CPMP, and does not differ from the nonpregnant group. In a month after vaccination the level of seroprotective against A/H1N1/v was 77.0%, A/H3N2 — 88.9%, B — 85.2% after vaccination in II trimester, and 87.0; 87.0; 91.35% in III trimester of gestation. The factor of seroconversion after vaccination in II trimester for A/H1N1/v was equal to 6.5, A/H3N2 — 7.2, B — 6.5, after vaccination in III trimester of pregnancy: 7.1, 6.5 and 5.1 correspondingly. At the same time revealed accelerated decline in antibody titer against influenza in pregnant women compared to nonpregnant women in a year after immunization The set of results of the study can be concluded that adjuvant trivalent subunit vaccine effective in vaccination of pregnant women in II and III trimester of pregnancy, and it is able to effectively provide immune protection against viruses of the flu A and B within all pregnancy long.M. P. KostinovA. P. CherdantsevA. D. ShmitkoD. A. PraulovaA. D. ProtasovU. A. DagilT. A. KostinovaN. K. AkhmatovaE. A. ChromovaA. A. RyzhovD. A. BlagovidovV. B. PolishchukO. O. MagarshakE. S. KorovkinaSankt-Peterburg : NIIÈM imeni Pasteraarticleinfluenzaimmunoadjuvant vaccinesvaccination of pregnant womensubunit trivalent immunoadjuvant vaccinepostvaccinal immune responseInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 7, Iss 2, Pp 193-202 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza immunoadjuvant vaccines vaccination of pregnant women subunit trivalent immunoadjuvant vaccine postvaccinal immune response Infectious and parasitic diseases RC109-216
spellingShingle	influenza immunoadjuvant vaccines vaccination of pregnant women subunit trivalent immunoadjuvant vaccine postvaccinal immune response Infectious and parasitic diseases RC109-216 M. P. Kostinov A. P. Cherdantsev A. D. Shmitko D. A. Praulova A. D. Protasov U. A. Dagil T. A. Kostinova N. K. Akhmatova E. A. Chromova A. A. Ryzhov D. A. Blagovidov V. B. Polishchuk O. O. Magarshak E. S. Korovkina IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN
description	Recent epidemiological events showed that pregnant women are the most vulnerable part of population if there is the flu in the country and they die much more often than the rest part of people. That is why influenza vaccination of population including pregnant women is one of the priorities of public health service in our state. Worldwide experience of influenza vaccination of either adults or children by new adjuvant vaccine has caused our research of its efficiency among pregnant women. The aim of the study was to investigate the level of antibodies to influenza virus strain A/H1N1/v, A/H3N2 and B in pregnant women vaccinated adjuvant trivalent subunit vaccine. Our research is randomized and comparative on parallel groups. It was carried out within the demands of Russian Federation and International ethic norms adapted to such kind of researches. Evaluation of the immunogenicity of the vaccine was conducted in 27 pregnant women in the II trimester of gestation, and in 23 pregnant women in the III trimester of gestation, 19 non-pregnant women was in the control group. The level of antibodies in the serum was determined using a reaction of hemagglutination inhibition before and 1, 3, 6, 9 and 12 months after the vaccination. Revealed that influenza vaccination of pregnant women in the II and III trimester, causes the increase in titers of antibodies to vaccine influenza strains A and B, to fully meet the required criteria CPMP, and does not differ from the nonpregnant group. In a month after vaccination the level of seroprotective against A/H1N1/v was 77.0%, A/H3N2 — 88.9%, B — 85.2% after vaccination in II trimester, and 87.0; 87.0; 91.35% in III trimester of gestation. The factor of seroconversion after vaccination in II trimester for A/H1N1/v was equal to 6.5, A/H3N2 — 7.2, B — 6.5, after vaccination in III trimester of pregnancy: 7.1, 6.5 and 5.1 correspondingly. At the same time revealed accelerated decline in antibody titer against influenza in pregnant women compared to nonpregnant women in a year after immunization The set of results of the study can be concluded that adjuvant trivalent subunit vaccine effective in vaccination of pregnant women in II and III trimester of pregnancy, and it is able to effectively provide immune protection against viruses of the flu A and B within all pregnancy long.
format	article
author	M. P. Kostinov A. P. Cherdantsev A. D. Shmitko D. A. Praulova A. D. Protasov U. A. Dagil T. A. Kostinova N. K. Akhmatova E. A. Chromova A. A. Ryzhov D. A. Blagovidov V. B. Polishchuk O. O. Magarshak E. S. Korovkina
author_facet	M. P. Kostinov A. P. Cherdantsev A. D. Shmitko D. A. Praulova A. D. Protasov U. A. Dagil T. A. Kostinova N. K. Akhmatova E. A. Chromova A. A. Ryzhov D. A. Blagovidov V. B. Polishchuk O. O. Magarshak E. S. Korovkina
author_sort	M. P. Kostinov
title	IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN
title_short	IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN
title_full	IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN
title_fullStr	IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN
title_full_unstemmed	IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN
title_sort	immunogenicity of adjuvant influenza vaccine for pregnant women
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2017
url	https://doaj.org/article/4db111c8f3844735b1f77704bb4d194f
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IMMUNOGENICITY OF ADJUVANT INFLUENZA VACCINE FOR PREGNANT WOMEN

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