Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell response...

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Autores principales:	Ting Wu, Jing Guan, Andreas Handel, David C. Tscharke, John Sidney, Alessandro Sette, Linda M. Wakim, Xavier Y. X. Sng, Paul G. Thomas, Nathan P. Croft, Anthony W. Purcell, Nicole L. La Gruta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4db3dda319094990b8faec74a9a13815
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spelling	oai:doaj.org-article:4db3dda319094990b8faec74a9a138152021-12-02T16:57:30ZQuantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses10.1038/s41467-019-10661-82041-1723https://doaj.org/article/4db3dda319094990b8faec74a9a138152019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10661-8https://doaj.org/toc/2041-1723CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell responses in infected mice.Ting WuJing GuanAndreas HandelDavid C. TscharkeJohn SidneyAlessandro SetteLinda M. WakimXavier Y. X. SngPaul G. ThomasNathan P. CroftAnthony W. PurcellNicole L. La GrutaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ting Wu Jing Guan Andreas Handel David C. Tscharke John Sidney Alessandro Sette Linda M. Wakim Xavier Y. X. Sng Paul G. Thomas Nathan P. Croft Anthony W. Purcell Nicole L. La Gruta Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
description	CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell responses in infected mice.
format	article
author	Ting Wu Jing Guan Andreas Handel David C. Tscharke John Sidney Alessandro Sette Linda M. Wakim Xavier Y. X. Sng Paul G. Thomas Nathan P. Croft Anthony W. Purcell Nicole L. La Gruta
author_facet	Ting Wu Jing Guan Andreas Handel David C. Tscharke John Sidney Alessandro Sette Linda M. Wakim Xavier Y. X. Sng Paul G. Thomas Nathan P. Croft Anthony W. Purcell Nicole L. La Gruta
author_sort	Ting Wu
title	Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
title_short	Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
title_full	Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
title_fullStr	Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
title_full_unstemmed	Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
title_sort	quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza ctl responses
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4db3dda319094990b8faec74a9a13815
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Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

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