Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting...

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Autores principales:	Ricardo M. Gouveia, Guillaume Lepert, Suneel Gupta, Rajiv R. Mohan, Carl Paterson, Che J. Connon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4db489443ac3438cb327cb65509749c4
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spelling	oai:doaj.org-article:4db489443ac3438cb327cb65509749c42021-12-02T17:01:57ZAssessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation10.1038/s41467-019-09331-62041-1723https://doaj.org/article/4db489443ac3438cb327cb65509749c42019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09331-6https://doaj.org/toc/2041-1723The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting in regeneration.Ricardo M. GouveiaGuillaume LepertSuneel GuptaRajiv R. MohanCarl PatersonChe J. ConnonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ricardo M. Gouveia Guillaume Lepert Suneel Gupta Rajiv R. Mohan Carl Paterson Che J. Connon Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
description	The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting in regeneration.
format	article
author	Ricardo M. Gouveia Guillaume Lepert Suneel Gupta Rajiv R. Mohan Carl Paterson Che J. Connon
author_facet	Ricardo M. Gouveia Guillaume Lepert Suneel Gupta Rajiv R. Mohan Carl Paterson Che J. Connon
author_sort	Ricardo M. Gouveia
title	Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_short	Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_full	Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_fullStr	Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_full_unstemmed	Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
title_sort	assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4db489443ac3438cb327cb65509749c4
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Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

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