Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia

Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to en...

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Autores principales:	Chen-Hung Lee, Kuo-Sheng Liu, Julien George Roth, Kuo-Chun Hung, Yen-Wei Liu, Shin-Huei Wang, Chi-Ching Kuo, Shih-Jung Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug-loaded nanofibers telmisartan PLGA controlled release Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4db7564bc9ae48a28ddd05095c219495
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spelling	oai:doaj.org-article:4db7564bc9ae48a28ddd05095c2194952021-11-25T18:40:24ZTelmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia10.3390/pharmaceutics131117561999-4923https://doaj.org/article/4db7564bc9ae48a28ddd05095c2194952021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1756https://doaj.org/toc/1999-4923Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to enhance endothelial function and limit neointimal hyperplasia. This study utilized hybrid biodegradable/stent nanofibers to facilitate sustained and local delivery of telmisartan to injured arterial vessels. Telmisartan and poly(<span style="font-variant: small-caps;">d,l</span>)-lactide-<i>co</i>-glycolide (PLGA) (75:25) were dissolved in hexafluoroisopropyl alcohol and electrospun into biodegradable nanofibrous tubes which were coated onto metal stents. By releasing 20% of the loaded telmisartan in 30 days, these hybrid biodegradable/stent telmisartan-loaded nanofibers increased the migration of endothelial progenitor cells in vitro, promoted endothelialization, and reduced intimal hyperplasia. As such, this work provides insights into the use of PLGA nanofibers for treating patients with an increased risk of stent restenosis.Chen-Hung LeeKuo-Sheng LiuJulien George RothKuo-Chun HungYen-Wei LiuShin-Huei WangChi-Ching KuoShih-Jung LiuMDPI AGarticledrug-loaded nanofiberstelmisartanPLGAcontrolled releasePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1756, p 1756 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-loaded nanofibers telmisartan PLGA controlled release Pharmacy and materia medica RS1-441
spellingShingle	drug-loaded nanofibers telmisartan PLGA controlled release Pharmacy and materia medica RS1-441 Chen-Hung Lee Kuo-Sheng Liu Julien George Roth Kuo-Chun Hung Yen-Wei Liu Shin-Huei Wang Chi-Ching Kuo Shih-Jung Liu Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia
description	Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to enhance endothelial function and limit neointimal hyperplasia. This study utilized hybrid biodegradable/stent nanofibers to facilitate sustained and local delivery of telmisartan to injured arterial vessels. Telmisartan and poly(<span style="font-variant: small-caps;">d,l</span>)-lactide-<i>co</i>-glycolide (PLGA) (75:25) were dissolved in hexafluoroisopropyl alcohol and electrospun into biodegradable nanofibrous tubes which were coated onto metal stents. By releasing 20% of the loaded telmisartan in 30 days, these hybrid biodegradable/stent telmisartan-loaded nanofibers increased the migration of endothelial progenitor cells in vitro, promoted endothelialization, and reduced intimal hyperplasia. As such, this work provides insights into the use of PLGA nanofibers for treating patients with an increased risk of stent restenosis.
format	article
author	Chen-Hung Lee Kuo-Sheng Liu Julien George Roth Kuo-Chun Hung Yen-Wei Liu Shin-Huei Wang Chi-Ching Kuo Shih-Jung Liu
author_facet	Chen-Hung Lee Kuo-Sheng Liu Julien George Roth Kuo-Chun Hung Yen-Wei Liu Shin-Huei Wang Chi-Ching Kuo Shih-Jung Liu
author_sort	Chen-Hung Lee
title	Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia
title_short	Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia
title_full	Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia
title_fullStr	Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia
title_full_unstemmed	Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia
title_sort	telmisartan loaded nanofibers enhance re-endothelialization and inhibit neointimal hyperplasia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4db7564bc9ae48a28ddd05095c219495
work_keys_str_mv	AT chenhunglee telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia AT kuoshengliu telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia AT juliengeorgeroth telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia AT kuochunhung telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia AT yenweiliu telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia AT shinhueiwang telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia AT chichingkuo telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia AT shihjungliu telmisartanloadednanofibersenhancereendothelializationandinhibitneointimalhyperplasia
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Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia

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