Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin condensate formation and degradation by autophagy.

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Autores principales:	Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig, Sascha Martens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4db780a5a06e48a0bc6214ed5a5ead08
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spelling	oai:doaj.org-article:4db780a5a06e48a0bc6214ed5a5ead082021-12-02T19:10:37ZReconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation10.1038/s41467-021-25572-w2041-1723https://doaj.org/article/4db780a5a06e48a0bc6214ed5a5ead082021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25572-whttps://doaj.org/toc/2041-1723Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin condensate formation and degradation by autophagy.Eleonora TurcoAdriana SavovaFlora GereLuca FerrariJulia RomanovMartina SchuschnigSascha MartensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eleonora Turco Adriana Savova Flora Gere Luca Ferrari Julia Romanov Martina Schuschnig Sascha Martens Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
description	Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin condensate formation and degradation by autophagy.
format	article
author	Eleonora Turco Adriana Savova Flora Gere Luca Ferrari Julia Romanov Martina Schuschnig Sascha Martens
author_facet	Eleonora Turco Adriana Savova Flora Gere Luca Ferrari Julia Romanov Martina Schuschnig Sascha Martens
author_sort	Eleonora Turco
title	Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
title_short	Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
title_full	Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
title_fullStr	Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
title_full_unstemmed	Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
title_sort	reconstitution defines the roles of p62, nbr1 and tax1bp1 in ubiquitin condensate formation and autophagy initiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4db780a5a06e48a0bc6214ed5a5ead08
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Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

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