Membrane Binding and Subcellular Localization of Retroviral Gag Proteins Are Differentially Regulated by MA Interactions with Phosphatidylinositol-(4,5)-Bisphosphate and RNA

Membrane Binding and Subcellular Localization of Retroviral Gag Proteins Are Differentially Regulated by MA Interactions with Phosphatidylinositol-(4,5)-Bisphosphate and RNA

ABSTRACT The matrix (MA) domain of HIV-1 mediates proper Gag localization and membrane binding via interaction with a plasma-membrane (PM)-specific acidic phospholipid, phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2]. HIV-1 MA also interacts with RNA, which prevents Gag from binding to membranes...

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Autores principales: Jingga Inlora, David R. Collins, Marc E. Trubin, Ji Yeon J. Chung, Akira Ono
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/4db8882117654bb988fdb5d5df3fb8f4
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