Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria

Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea Abstract: Emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious disease...

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Autores principales:	Ramasamy M, Lee JH, Lee J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	antibiofilm biocompatible Caenorhabditis elegans cinnamaldehyde gold nanoparticles Staphylococcus aureus Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4dbaa361954a46919edca3b0ca33347b
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spelling	oai:doaj.org-article:4dbaa361954a46919edca3b0ca33347b2021-12-02T03:11:40ZDevelopment of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria1178-2013https://doaj.org/article/4dbaa361954a46919edca3b0ca33347b2017-04-01T00:00:00Zhttps://www.dovepress.com/development-of-gold-nanoparticles-coated-with-silica-containing-the-an-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea Abstract: Emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious diseases caused by bacterial pathogens. In this study, the authors used the antibiofilm activity of the naturally occurring antimicrobial cinnamaldehyde (CNMA) conjugated to the surface of gold nanoparticles (GNPs) to deliver CNMA efficiently and eradicate biofilms of Gram-negative organisms (enterohemorrhagic Escherichia coli O157:H7, and Pseudomonas aeruginosa), Gram positive (methicillin-sensitive Staphylococcus aureus organisms, and methicillin-resistant Staphylococcus aureus) bacteria. CNMA-GNPs containing 0.005% (v/v) of CNMA were found to inhibit biofilm formation efficiently. The distributions of nanoparticles in biofilm cells and their biofilm disruption activities, including distorted cell morphology, were determined by transmission electron microscopy. In addition to their antibiofilm activities, CNMA-GNPs attenuated S. aureus virulence and protected Caenorhabditis elegans (C. elegans) worms. Here, the authors report the antibiofilm effects of CNMA-GNPs and suggest that they could be used to treat pathogenic bacterial infections in vivo. Keywords: antibiofilm, biocompatible, Caenorhabditis elegans, cinnamaldehyde, gold nanoparticles, Staphylococcus aureusRamasamy MLee JHLee JDove Medical PressarticleantibiofilmbiocompatibleCaenorhabditis eleganscinnamaldehydegold nanoparticlesStaphylococcus aureusMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2813-2828 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiofilm biocompatible Caenorhabditis elegans cinnamaldehyde gold nanoparticles Staphylococcus aureus Medicine (General) R5-920
spellingShingle	antibiofilm biocompatible Caenorhabditis elegans cinnamaldehyde gold nanoparticles Staphylococcus aureus Medicine (General) R5-920 Ramasamy M Lee JH Lee J Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
description	Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea Abstract: Emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious diseases caused by bacterial pathogens. In this study, the authors used the antibiofilm activity of the naturally occurring antimicrobial cinnamaldehyde (CNMA) conjugated to the surface of gold nanoparticles (GNPs) to deliver CNMA efficiently and eradicate biofilms of Gram-negative organisms (enterohemorrhagic Escherichia coli O157:H7, and Pseudomonas aeruginosa), Gram positive (methicillin-sensitive Staphylococcus aureus organisms, and methicillin-resistant Staphylococcus aureus) bacteria. CNMA-GNPs containing 0.005% (v/v) of CNMA were found to inhibit biofilm formation efficiently. The distributions of nanoparticles in biofilm cells and their biofilm disruption activities, including distorted cell morphology, were determined by transmission electron microscopy. In addition to their antibiofilm activities, CNMA-GNPs attenuated S. aureus virulence and protected Caenorhabditis elegans (C. elegans) worms. Here, the authors report the antibiofilm effects of CNMA-GNPs and suggest that they could be used to treat pathogenic bacterial infections in vivo. Keywords: antibiofilm, biocompatible, Caenorhabditis elegans, cinnamaldehyde, gold nanoparticles, Staphylococcus aureus
format	article
author	Ramasamy M Lee JH Lee J
author_facet	Ramasamy M Lee JH Lee J
author_sort	Ramasamy M
title	Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
title_short	Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
title_full	Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
title_fullStr	Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
title_full_unstemmed	Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
title_sort	development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4dbaa361954a46919edca3b0ca33347b
work_keys_str_mv	AT ramasamym developmentofgoldnanoparticlescoatedwithsilicacontainingtheantibiofilmdrugcinnamaldehydeandtheireffectsonpathogenicbacteria AT leejh developmentofgoldnanoparticlescoatedwithsilicacontainingtheantibiofilmdrugcinnamaldehydeandtheireffectsonpathogenicbacteria AT leej developmentofgoldnanoparticlescoatedwithsilicacontainingtheantibiofilmdrugcinnamaldehydeandtheireffectsonpathogenicbacteria
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Development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria

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