Functional implications of PABPC1 in the development of ovarian cancer

This research aimed to probe the expression characteristics of poly(A)-binding protein cytoplasmic 1 (PABPC1) and its role on the phenotype of ovarian cancer (OC) cells and to further investigate the possible underlying mechanism. The expression of PABPC1 was analyzed according to the data from gene...

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Autores principales:	Feng Cong, Han Yan-Hua, Qi Na, Li Jia, Sheng Qing-Hua, Liu Yu, Yang Li-Li
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	pabpc1 ovarian carcinoma proliferation invasion and migration emt Medicine R
Acceso en línea:	https://doaj.org/article/4dbe76b25eaa4bf1a2f25d5eb503f790
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spelling	oai:doaj.org-article:4dbe76b25eaa4bf1a2f25d5eb503f7902021-12-05T14:10:54ZFunctional implications of PABPC1 in the development of ovarian cancer2391-546310.1515/med-2021-0278https://doaj.org/article/4dbe76b25eaa4bf1a2f25d5eb503f7902021-05-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0278https://doaj.org/toc/2391-5463This research aimed to probe the expression characteristics of poly(A)-binding protein cytoplasmic 1 (PABPC1) and its role on the phenotype of ovarian cancer (OC) cells and to further investigate the possible underlying mechanism. The expression of PABPC1 was analyzed according to the data from gene expression omnibus, The Cancer Genome Atlas (TCGA) and Oncomine databases and the RNA sequencing data set from TCGA were downloaded for evaluating the prognostic values. We revealed that compared with the healthy samples, PABPC1 was upregulated in OC samples. High expression of PABPC1 had a connection with a shorter survival for patients with OC. Loss and gain of function assays revealed that silencing PABPC1 significantly suppressed the viability, invasion and migration of SK-OV-3 cells, while PABPC1 overexpression in A2780 cells showed the reverse outcomes. Moreover, Western blot demonstrated that silencing PABPC1 notably inactivated the epithelial–mesenchymal transition (EMT) process, while upregulation of PABPC1 promoted the mitigation of epithelial phenotype and the acquisition of mesenchymal phenotype. Taken together, PABPC1 was upregulated in OC cells and served as a carcinogene to promote the OC cell growth and invasion partly by modulating the EMT process, which implied that PABPC1 might be considered as a useful biomarker for OC therapeutics.Feng CongHan Yan-HuaQi NaLi JiaSheng Qing-HuaLiu YuYang Li-LiDe Gruyterarticlepabpc1ovarian carcinomaproliferationinvasion and migrationemtMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 805-815 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pabpc1 ovarian carcinoma proliferation invasion and migration emt Medicine R
spellingShingle	pabpc1 ovarian carcinoma proliferation invasion and migration emt Medicine R Feng Cong Han Yan-Hua Qi Na Li Jia Sheng Qing-Hua Liu Yu Yang Li-Li Functional implications of PABPC1 in the development of ovarian cancer
description	This research aimed to probe the expression characteristics of poly(A)-binding protein cytoplasmic 1 (PABPC1) and its role on the phenotype of ovarian cancer (OC) cells and to further investigate the possible underlying mechanism. The expression of PABPC1 was analyzed according to the data from gene expression omnibus, The Cancer Genome Atlas (TCGA) and Oncomine databases and the RNA sequencing data set from TCGA were downloaded for evaluating the prognostic values. We revealed that compared with the healthy samples, PABPC1 was upregulated in OC samples. High expression of PABPC1 had a connection with a shorter survival for patients with OC. Loss and gain of function assays revealed that silencing PABPC1 significantly suppressed the viability, invasion and migration of SK-OV-3 cells, while PABPC1 overexpression in A2780 cells showed the reverse outcomes. Moreover, Western blot demonstrated that silencing PABPC1 notably inactivated the epithelial–mesenchymal transition (EMT) process, while upregulation of PABPC1 promoted the mitigation of epithelial phenotype and the acquisition of mesenchymal phenotype. Taken together, PABPC1 was upregulated in OC cells and served as a carcinogene to promote the OC cell growth and invasion partly by modulating the EMT process, which implied that PABPC1 might be considered as a useful biomarker for OC therapeutics.
format	article
author	Feng Cong Han Yan-Hua Qi Na Li Jia Sheng Qing-Hua Liu Yu Yang Li-Li
author_facet	Feng Cong Han Yan-Hua Qi Na Li Jia Sheng Qing-Hua Liu Yu Yang Li-Li
author_sort	Feng Cong
title	Functional implications of PABPC1 in the development of ovarian cancer
title_short	Functional implications of PABPC1 in the development of ovarian cancer
title_full	Functional implications of PABPC1 in the development of ovarian cancer
title_fullStr	Functional implications of PABPC1 in the development of ovarian cancer
title_full_unstemmed	Functional implications of PABPC1 in the development of ovarian cancer
title_sort	functional implications of pabpc1 in the development of ovarian cancer
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/4dbe76b25eaa4bf1a2f25d5eb503f790
work_keys_str_mv	AT fengcong functionalimplicationsofpabpc1inthedevelopmentofovariancancer AT hanyanhua functionalimplicationsofpabpc1inthedevelopmentofovariancancer AT qina functionalimplicationsofpabpc1inthedevelopmentofovariancancer AT lijia functionalimplicationsofpabpc1inthedevelopmentofovariancancer AT shengqinghua functionalimplicationsofpabpc1inthedevelopmentofovariancancer AT liuyu functionalimplicationsofpabpc1inthedevelopmentofovariancancer AT yanglili functionalimplicationsofpabpc1inthedevelopmentofovariancancer
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Functional implications of PABPC1 in the development of ovarian cancer

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