Risk of stroke in cancer survivors using a propensity score-matched cohort analysis

Abstract Little is known about the risk of cerebrovascular disease in cancer survivors. We aimed to assess the association between incident cancer and the subsequent risk of stroke using a large-scale, population-based prospective study. 74,530 Japanese aged between 40 and 69 years at baseline study...

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Autores principales:	Eiko Saito, Manami Inoue, Norie Sawada, Yoshihiro Kokubo, Kazumasa Yamagishi, Hiroyasu Iso, Taichi Shimazu, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane, JPHC Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4dc3cf3de7124a549d954058926e2305
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spelling	oai:doaj.org-article:4dc3cf3de7124a549d954058926e23052021-12-02T15:53:45ZRisk of stroke in cancer survivors using a propensity score-matched cohort analysis10.1038/s41598-021-83368-w2045-2322https://doaj.org/article/4dc3cf3de7124a549d954058926e23052021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83368-whttps://doaj.org/toc/2045-2322Abstract Little is known about the risk of cerebrovascular disease in cancer survivors. We aimed to assess the association between incident cancer and the subsequent risk of stroke using a large-scale, population-based prospective study. 74,530 Japanese aged between 40 and 69 years at baseline study were matched by the status of cancer diagnosis during follow-up using propensity score nearest-neighbor matching with allowance for replacement. A total of 2242 strokes were reported during 557,885 person-years of follow-up. Associations between incident cancer and the subsequent risk of all strokes, cerebral infarction, and intracerebral hemorrhage were assessed using a Cox proportional hazards model stratified on the propensity score-matched pairs. No significant association was observed between the status of cancer diagnosis of all types, gastric, colorectal and lung cancer, and subsequent occurrence of all strokes, cerebral infarction, and intracerebral hemorrhage. However, analysis by discrete time periods suggested an elevated risk in cancer patients for one to three months after a cancer diagnosis in all stroke (HR, 2.24; 95% CI, 1.06, 4.74) and cerebral infarction (HR, 2.62; 95% CI, 1.05, 6.53). This prospective cohort study found no association between the status of cancer diagnosis and the subsequent occurrence of all strokes and its subtypes during the entire follow-up period but suggested an increase in stroke risk during the active phase of malignancy.Eiko SaitoManami InoueNorie SawadaYoshihiro KokuboKazumasa YamagishiHiroyasu IsoTaichi ShimazuTaiki YamajiMotoki IwasakiShoichiro TsuganeJPHC Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eiko Saito Manami Inoue Norie Sawada Yoshihiro Kokubo Kazumasa Yamagishi Hiroyasu Iso Taichi Shimazu Taiki Yamaji Motoki Iwasaki Shoichiro Tsugane JPHC Study Group Risk of stroke in cancer survivors using a propensity score-matched cohort analysis
description	Abstract Little is known about the risk of cerebrovascular disease in cancer survivors. We aimed to assess the association between incident cancer and the subsequent risk of stroke using a large-scale, population-based prospective study. 74,530 Japanese aged between 40 and 69 years at baseline study were matched by the status of cancer diagnosis during follow-up using propensity score nearest-neighbor matching with allowance for replacement. A total of 2242 strokes were reported during 557,885 person-years of follow-up. Associations between incident cancer and the subsequent risk of all strokes, cerebral infarction, and intracerebral hemorrhage were assessed using a Cox proportional hazards model stratified on the propensity score-matched pairs. No significant association was observed between the status of cancer diagnosis of all types, gastric, colorectal and lung cancer, and subsequent occurrence of all strokes, cerebral infarction, and intracerebral hemorrhage. However, analysis by discrete time periods suggested an elevated risk in cancer patients for one to three months after a cancer diagnosis in all stroke (HR, 2.24; 95% CI, 1.06, 4.74) and cerebral infarction (HR, 2.62; 95% CI, 1.05, 6.53). This prospective cohort study found no association between the status of cancer diagnosis and the subsequent occurrence of all strokes and its subtypes during the entire follow-up period but suggested an increase in stroke risk during the active phase of malignancy.
format	article
author	Eiko Saito Manami Inoue Norie Sawada Yoshihiro Kokubo Kazumasa Yamagishi Hiroyasu Iso Taichi Shimazu Taiki Yamaji Motoki Iwasaki Shoichiro Tsugane JPHC Study Group
author_facet	Eiko Saito Manami Inoue Norie Sawada Yoshihiro Kokubo Kazumasa Yamagishi Hiroyasu Iso Taichi Shimazu Taiki Yamaji Motoki Iwasaki Shoichiro Tsugane JPHC Study Group
author_sort	Eiko Saito
title	Risk of stroke in cancer survivors using a propensity score-matched cohort analysis
title_short	Risk of stroke in cancer survivors using a propensity score-matched cohort analysis
title_full	Risk of stroke in cancer survivors using a propensity score-matched cohort analysis
title_fullStr	Risk of stroke in cancer survivors using a propensity score-matched cohort analysis
title_full_unstemmed	Risk of stroke in cancer survivors using a propensity score-matched cohort analysis
title_sort	risk of stroke in cancer survivors using a propensity score-matched cohort analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4dc3cf3de7124a549d954058926e2305
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Risk of stroke in cancer survivors using a propensity score-matched cohort analysis

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