Progress of Phototherapy Applications in the Treatment of Bone Cancer

Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells ma...

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Autores principales:	Jiachen Sun, Fei Xing, Joy Braun, Frank Traub, Pol Maria Rommens, Zhou Xiang, Ulrike Ritz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	phototherapy photodynamic therapy photothermal therapy bone cancer tumor therapy nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4dc57b10cb894af3a97fe44a16f4481c
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spelling	oai:doaj.org-article:4dc57b10cb894af3a97fe44a16f4481c2021-11-11T16:50:01ZProgress of Phototherapy Applications in the Treatment of Bone Cancer10.3390/ijms2221113541422-00671661-6596https://doaj.org/article/4dc57b10cb894af3a97fe44a16f4481c2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11354https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT), is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wavelength, the photosensitizer (PS) in PDT can cause the increase of intracellular ROS and the photothermal agent (PTA) in PTT can induce photothermal conversion, leading to the tumoricidal effects. In this review, the progress of PT applications in the treatment of bone cancer has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. This review provides the current state of the art regarding PDT and PTT in bone cancer and inspiration for future studies on PT.Jiachen SunFei XingJoy BraunFrank TraubPol Maria RommensZhou XiangUlrike RitzMDPI AGarticlephototherapyphotodynamic therapyphotothermal therapybone cancertumor therapynanoparticlesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11354, p 11354 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phototherapy photodynamic therapy photothermal therapy bone cancer tumor therapy nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	phototherapy photodynamic therapy photothermal therapy bone cancer tumor therapy nanoparticles Biology (General) QH301-705.5 Chemistry QD1-999 Jiachen Sun Fei Xing Joy Braun Frank Traub Pol Maria Rommens Zhou Xiang Ulrike Ritz Progress of Phototherapy Applications in the Treatment of Bone Cancer
description	Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT), is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wavelength, the photosensitizer (PS) in PDT can cause the increase of intracellular ROS and the photothermal agent (PTA) in PTT can induce photothermal conversion, leading to the tumoricidal effects. In this review, the progress of PT applications in the treatment of bone cancer has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. This review provides the current state of the art regarding PDT and PTT in bone cancer and inspiration for future studies on PT.
format	article
author	Jiachen Sun Fei Xing Joy Braun Frank Traub Pol Maria Rommens Zhou Xiang Ulrike Ritz
author_facet	Jiachen Sun Fei Xing Joy Braun Frank Traub Pol Maria Rommens Zhou Xiang Ulrike Ritz
author_sort	Jiachen Sun
title	Progress of Phototherapy Applications in the Treatment of Bone Cancer
title_short	Progress of Phototherapy Applications in the Treatment of Bone Cancer
title_full	Progress of Phototherapy Applications in the Treatment of Bone Cancer
title_fullStr	Progress of Phototherapy Applications in the Treatment of Bone Cancer
title_full_unstemmed	Progress of Phototherapy Applications in the Treatment of Bone Cancer
title_sort	progress of phototherapy applications in the treatment of bone cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4dc57b10cb894af3a97fe44a16f4481c
work_keys_str_mv	AT jiachensun progressofphototherapyapplicationsinthetreatmentofbonecancer AT feixing progressofphototherapyapplicationsinthetreatmentofbonecancer AT joybraun progressofphototherapyapplicationsinthetreatmentofbonecancer AT franktraub progressofphototherapyapplicationsinthetreatmentofbonecancer AT polmariarommens progressofphototherapyapplicationsinthetreatmentofbonecancer AT zhouxiang progressofphototherapyapplicationsinthetreatmentofbonecancer AT ulrikeritz progressofphototherapyapplicationsinthetreatmentofbonecancer
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Progress of Phototherapy Applications in the Treatment of Bone Cancer

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