The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival...

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Autores principales:	Lijian Shao, Jianhui Chang, Wei Feng, Xiaoyan Wang, Elizabeth A. Williamson, Ying Li, Amir Schajnovitz, David Scadden, Luke J. Mortensen, Charles P. Lin, Linheng Li, Ariel Paulson, James Downing, Daohong Zhou, Robert A. Hromas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4dc6c1370dff42ada8f865c1c679a6ac
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spelling	oai:doaj.org-article:4dc6c1370dff42ada8f865c1c679a6ac2021-12-02T15:34:46ZThe Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow10.1038/s41467-018-04716-52041-1723https://doaj.org/article/4dc6c1370dff42ada8f865c1c679a6ac2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04716-5https://doaj.org/toc/2041-1723Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival signaling.Lijian ShaoJianhui ChangWei FengXiaoyan WangElizabeth A. WilliamsonYing LiAmir SchajnovitzDavid ScaddenLuke J. MortensenCharles P. LinLinheng LiAriel PaulsonJames DowningDaohong ZhouRobert A. HromasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lijian Shao Jianhui Chang Wei Feng Xiaoyan Wang Elizabeth A. Williamson Ying Li Amir Schajnovitz David Scadden Luke J. Mortensen Charles P. Lin Linheng Li Ariel Paulson James Downing Daohong Zhou Robert A. Hromas The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
description	Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival signaling.
format	article
author	Lijian Shao Jianhui Chang Wei Feng Xiaoyan Wang Elizabeth A. Williamson Ying Li Amir Schajnovitz David Scadden Luke J. Mortensen Charles P. Lin Linheng Li Ariel Paulson James Downing Daohong Zhou Robert A. Hromas
author_facet	Lijian Shao Jianhui Chang Wei Feng Xiaoyan Wang Elizabeth A. Williamson Ying Li Amir Schajnovitz David Scadden Luke J. Mortensen Charles P. Lin Linheng Li Ariel Paulson James Downing Daohong Zhou Robert A. Hromas
author_sort	Lijian Shao
title	The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
title_short	The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
title_full	The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
title_fullStr	The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
title_full_unstemmed	The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
title_sort	wave2 scaffold hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4dc6c1370dff42ada8f865c1c679a6ac
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The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

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