Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease

Abstract Perfusion catheters have recently emerged as a novel approach to deliver liquid anti-proliferative agents into flow obstructed arterial segments. The purpose of this study was to determine the impact of luminal delivery pressure on liquid drug penetration into the vessel wall. An ex vivo mo...

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Autores principales:	Marzieh K. Atigh, Emily Goel, Megan Erwin, Ricky Greer, Jacques Ohayon, Roderic I. Pettigrew, Saami K. Yazdani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4dc75708f326434e88b03657883d5e7b
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spelling	oai:doaj.org-article:4dc75708f326434e88b03657883d5e7b2021-12-02T17:26:55ZPrecision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease10.1038/s41598-021-98063-z2045-2322https://doaj.org/article/4dc75708f326434e88b03657883d5e7b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98063-zhttps://doaj.org/toc/2045-2322Abstract Perfusion catheters have recently emerged as a novel approach to deliver liquid anti-proliferative agents into flow obstructed arterial segments. The purpose of this study was to determine the impact of luminal delivery pressure on liquid drug penetration into the vessel wall. An ex vivo model using harvested porcine carotid arteries and a two-dimensional computational model were utilized to determine the impact of delivery pressure of liquid therapy into the arterial wall. A pig peripheral injury model determined the impact of intra-luminal delivery pressure on drug retention. Ex vivo results demonstrated that depth of fluid penetration varies from 6.93 ± 1.90% at 0 atm to 27.75 ± 6.61% penetration of the medial layer at 0.4 atm. Computational results had similar outcomes, as penetration varied between 4.4% and 22.84%. The in vivo results demonstrated significant increase in drug delivery to the arterial tissue at 0.4 atm versus 0.1 atm at 1 h (23.43 ± 13.59 ng/mg vs. 2.49 ± 1.81 ng/mg, p = 0.026) and 7 days (0.50 ± 0.39 ng/mg vs. 0.018 ± 0.023 ng/mg, p = 0.0496). The result of this study provides an innovative strategic and technical approach to enable targeted liquid therapy.Marzieh K. AtighEmily GoelMegan ErwinRicky GreerJacques OhayonRoderic I. PettigrewSaami K. YazdaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marzieh K. Atigh Emily Goel Megan Erwin Ricky Greer Jacques Ohayon Roderic I. Pettigrew Saami K. Yazdani Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
description	Abstract Perfusion catheters have recently emerged as a novel approach to deliver liquid anti-proliferative agents into flow obstructed arterial segments. The purpose of this study was to determine the impact of luminal delivery pressure on liquid drug penetration into the vessel wall. An ex vivo model using harvested porcine carotid arteries and a two-dimensional computational model were utilized to determine the impact of delivery pressure of liquid therapy into the arterial wall. A pig peripheral injury model determined the impact of intra-luminal delivery pressure on drug retention. Ex vivo results demonstrated that depth of fluid penetration varies from 6.93 ± 1.90% at 0 atm to 27.75 ± 6.61% penetration of the medial layer at 0.4 atm. Computational results had similar outcomes, as penetration varied between 4.4% and 22.84%. The in vivo results demonstrated significant increase in drug delivery to the arterial tissue at 0.4 atm versus 0.1 atm at 1 h (23.43 ± 13.59 ng/mg vs. 2.49 ± 1.81 ng/mg, p = 0.026) and 7 days (0.50 ± 0.39 ng/mg vs. 0.018 ± 0.023 ng/mg, p = 0.0496). The result of this study provides an innovative strategic and technical approach to enable targeted liquid therapy.
format	article
author	Marzieh K. Atigh Emily Goel Megan Erwin Ricky Greer Jacques Ohayon Roderic I. Pettigrew Saami K. Yazdani
author_facet	Marzieh K. Atigh Emily Goel Megan Erwin Ricky Greer Jacques Ohayon Roderic I. Pettigrew Saami K. Yazdani
author_sort	Marzieh K. Atigh
title	Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
title_short	Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
title_full	Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
title_fullStr	Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
title_full_unstemmed	Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
title_sort	precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4dc75708f326434e88b03657883d5e7b
work_keys_str_mv	AT marziehkatigh precisiondeliveryofliquidtherapyintothearterialwallforthetreatmentofperipheralarterialdisease AT emilygoel precisiondeliveryofliquidtherapyintothearterialwallforthetreatmentofperipheralarterialdisease AT meganerwin precisiondeliveryofliquidtherapyintothearterialwallforthetreatmentofperipheralarterialdisease AT rickygreer precisiondeliveryofliquidtherapyintothearterialwallforthetreatmentofperipheralarterialdisease AT jacquesohayon precisiondeliveryofliquidtherapyintothearterialwallforthetreatmentofperipheralarterialdisease AT rodericipettigrew precisiondeliveryofliquidtherapyintothearterialwallforthetreatmentofperipheralarterialdisease AT saamikyazdani precisiondeliveryofliquidtherapyintothearterialwallforthetreatmentofperipheralarterialdisease
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Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease

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