Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

Juqun Xi,1–3 Lanyue Da,1 Changshui Yang,1 Rui Chen,4 Lizeng Gao,2 Lei Fan,5 Jie Han5 1Pharmacology Department, Medical School, Yangzhou University, 2Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 3Jiangsu Co-i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xi J, Da L, Yang C, Chen R, Gao L, Fan L, Han J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	PLGA nanoparticles polydopamine chemo-photothermal therapy smart theranostic agent Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4dc839859a364ac0b7892d740920c819
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4dc839859a364ac0b7892d740920c819
record_format	dspace
spelling	oai:doaj.org-article:4dc839859a364ac0b7892d740920c8192021-12-02T01:50:20ZMn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy1178-2013https://doaj.org/article/4dc839859a364ac0b7892d740920c8192017-04-01T00:00:00Zhttps://www.dovepress.com/mn2-coordinated-pdadoxplga-nanoparticles-as-a-smart-theranostic-agent--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Juqun Xi,1–3 Lanyue Da,1 Changshui Yang,1 Rui Chen,4 Lizeng Gao,2 Lei Fan,5 Jie Han5 1Pharmacology Department, Medical School, Yangzhou University, 2Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 3Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, 4Department of Nephrology, Subei People’s Hospital, Yangzhou University, 5School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China Abstract: Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn2+-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn2+ ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn2+-PDA@DOX/PLGA nanoparticles. In our system, Mn2+-PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn2+ could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn2+-PDA@DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties. Keywords: PLGA nanoparticles, polydopamine, chemo-photothermal therapy, smart theranostic agentXi JDa LYang CChen RGao LFan LHan JDove Medical PressarticlePLGA nanoparticlespolydopaminechemo-photothermal therapysmart theranostic agentMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 3331-3345 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	PLGA nanoparticles polydopamine chemo-photothermal therapy smart theranostic agent Medicine (General) R5-920
spellingShingle	PLGA nanoparticles polydopamine chemo-photothermal therapy smart theranostic agent Medicine (General) R5-920 Xi J Da L Yang C Chen R Gao L Fan L Han J Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
description	Juqun Xi,1–3 Lanyue Da,1 Changshui Yang,1 Rui Chen,4 Lizeng Gao,2 Lei Fan,5 Jie Han5 1Pharmacology Department, Medical School, Yangzhou University, 2Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, 3Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, 4Department of Nephrology, Subei People’s Hospital, Yangzhou University, 5School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China Abstract: Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn2+-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn2+ ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn2+-PDA@DOX/PLGA nanoparticles. In our system, Mn2+-PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn2+ could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn2+-PDA@DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties. Keywords: PLGA nanoparticles, polydopamine, chemo-photothermal therapy, smart theranostic agent
format	article
author	Xi J Da L Yang C Chen R Gao L Fan L Han J
author_facet	Xi J Da L Yang C Chen R Gao L Fan L Han J
author_sort	Xi J
title	Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_short	Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_full	Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_fullStr	Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_full_unstemmed	Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_sort	mn2+-coordinated pda@dox/plga nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4dc839859a364ac0b7892d740920c819
work_keys_str_mv	AT xij mn2coordinatedpdadoxplgananoparticlesasasmarttheranosticagentforsynergisticchemophotothermaltumortherapy AT dal mn2coordinatedpdadoxplgananoparticlesasasmarttheranosticagentforsynergisticchemophotothermaltumortherapy AT yangc mn2coordinatedpdadoxplgananoparticlesasasmarttheranosticagentforsynergisticchemophotothermaltumortherapy AT chenr mn2coordinatedpdadoxplgananoparticlesasasmarttheranosticagentforsynergisticchemophotothermaltumortherapy AT gaol mn2coordinatedpdadoxplgananoparticlesasasmarttheranosticagentforsynergisticchemophotothermaltumortherapy AT fanl mn2coordinatedpdadoxplgananoparticlesasasmarttheranosticagentforsynergisticchemophotothermaltumortherapy AT hanj mn2coordinatedpdadoxplgananoparticlesasasmarttheranosticagentforsynergisticchemophotothermaltumortherapy
_version_	1718402834412601344

Mn2+-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

Ejemplares similares