Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

KRASG12V and BRAFV600E are oncogenic mutations that activate ERK signalling. Here, the authors use single cell analysis in intestinal organoids and show that BRAFV600E activates ERK in all intestinal cell types, while KRASG12V induces ERK activation in only a subset of cells, depending on cell diffe...

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Autores principales: Raphael Brandt, Thomas Sell, Mareen Lüthen, Florian Uhlitz, Bertram Klinger, Pamela Riemer, Claudia Giesecke-Thiel, Silvia Schulze, Ismail Amr El-Shimy, Desiree Kunkel, Beatrix Fauler, Thorsten Mielke, Norbert Mages, Bernhard G. Herrmann, Christine Sers, Nils Blüthgen, Markus Morkel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4dc8feb67d344b21b71aced69388d1f8
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spelling oai:doaj.org-article:4dc8feb67d344b21b71aced69388d1f82021-12-02T14:40:19ZCell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium10.1038/s41467-019-10954-y2041-1723https://doaj.org/article/4dc8feb67d344b21b71aced69388d1f82019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10954-yhttps://doaj.org/toc/2041-1723KRASG12V and BRAFV600E are oncogenic mutations that activate ERK signalling. Here, the authors use single cell analysis in intestinal organoids and show that BRAFV600E activates ERK in all intestinal cell types, while KRASG12V induces ERK activation in only a subset of cells, depending on cell differentiation state.Raphael BrandtThomas SellMareen LüthenFlorian UhlitzBertram KlingerPamela RiemerClaudia Giesecke-ThielSilvia SchulzeIsmail Amr El-ShimyDesiree KunkelBeatrix FaulerThorsten MielkeNorbert MagesBernhard G. HerrmannChristine SersNils BlüthgenMarkus MorkelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Raphael Brandt
Thomas Sell
Mareen Lüthen
Florian Uhlitz
Bertram Klinger
Pamela Riemer
Claudia Giesecke-Thiel
Silvia Schulze
Ismail Amr El-Shimy
Desiree Kunkel
Beatrix Fauler
Thorsten Mielke
Norbert Mages
Bernhard G. Herrmann
Christine Sers
Nils Blüthgen
Markus Morkel
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
description KRASG12V and BRAFV600E are oncogenic mutations that activate ERK signalling. Here, the authors use single cell analysis in intestinal organoids and show that BRAFV600E activates ERK in all intestinal cell types, while KRASG12V induces ERK activation in only a subset of cells, depending on cell differentiation state.
format article
author Raphael Brandt
Thomas Sell
Mareen Lüthen
Florian Uhlitz
Bertram Klinger
Pamela Riemer
Claudia Giesecke-Thiel
Silvia Schulze
Ismail Amr El-Shimy
Desiree Kunkel
Beatrix Fauler
Thorsten Mielke
Norbert Mages
Bernhard G. Herrmann
Christine Sers
Nils Blüthgen
Markus Morkel
author_facet Raphael Brandt
Thomas Sell
Mareen Lüthen
Florian Uhlitz
Bertram Klinger
Pamela Riemer
Claudia Giesecke-Thiel
Silvia Schulze
Ismail Amr El-Shimy
Desiree Kunkel
Beatrix Fauler
Thorsten Mielke
Norbert Mages
Bernhard G. Herrmann
Christine Sers
Nils Blüthgen
Markus Morkel
author_sort Raphael Brandt
title Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
title_short Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
title_full Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
title_fullStr Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
title_full_unstemmed Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
title_sort cell type-dependent differential activation of erk by oncogenic kras in colon cancer and intestinal epithelium
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4dc8feb67d344b21b71aced69388d1f8
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