Glycomics for Microbes and Microbiologists
ABSTRACT The recent article “Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins” by Ielasi et al. describes a new development in microbial carbohydrate analysis [Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG, mB...
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American Society for Microbiology
2016
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oai:doaj.org-article:4dcb06d786e54f4bbd0af3f420c45c7a2021-11-15T15:50:19ZGlycomics for Microbes and Microbiologists10.1128/mBio.01224-162150-7511https://doaj.org/article/4dcb06d786e54f4bbd0af3f420c45c7a2016-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01224-16https://doaj.org/toc/2150-7511ABSTRACT The recent article “Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins” by Ielasi et al. describes a new development in microbial carbohydrate analysis [Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG, mBio 7(4):e00584-16, 2016, http://dx.doi.org/10.1128/mbio.00584-16]. Specific carbohydrate ligands have been identified from the patterns of lectin binding to oligosaccharides printed on a chip. The new technique links the output to a comprehensive glycan database and offers a number of data visualization options. The graphs highlight the occurrence of potential ligands, organized by organism, tissue, and patterns of association with disease states. The analysis has successfully predicted novel glycoprotein ligands for microbial lectins, including an interaction of E. coli FimH with HIV gp120.Peter N. LipkeAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 4 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Microbiology QR1-502 |
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Microbiology QR1-502 Peter N. Lipke Glycomics for Microbes and Microbiologists |
| description |
ABSTRACT The recent article “Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins” by Ielasi et al. describes a new development in microbial carbohydrate analysis [Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG, mBio 7(4):e00584-16, 2016, http://dx.doi.org/10.1128/mbio.00584-16]. Specific carbohydrate ligands have been identified from the patterns of lectin binding to oligosaccharides printed on a chip. The new technique links the output to a comprehensive glycan database and offers a number of data visualization options. The graphs highlight the occurrence of potential ligands, organized by organism, tissue, and patterns of association with disease states. The analysis has successfully predicted novel glycoprotein ligands for microbial lectins, including an interaction of E. coli FimH with HIV gp120. |
| format |
article |
| author |
Peter N. Lipke |
| author_facet |
Peter N. Lipke |
| author_sort |
Peter N. Lipke |
| title |
Glycomics for Microbes and Microbiologists |
| title_short |
Glycomics for Microbes and Microbiologists |
| title_full |
Glycomics for Microbes and Microbiologists |
| title_fullStr |
Glycomics for Microbes and Microbiologists |
| title_full_unstemmed |
Glycomics for Microbes and Microbiologists |
| title_sort |
glycomics for microbes and microbiologists |
| publisher |
American Society for Microbiology |
| publishDate |
2016 |
| url |
https://doaj.org/article/4dcb06d786e54f4bbd0af3f420c45c7a |
| work_keys_str_mv |
AT peternlipke glycomicsformicrobesandmicrobiologists |
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