Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.

<h4>Background</h4>Y-SNP haplogroup G (hgG), defined by Y-SNP marker M201, is relatively uncommon in the United States general population, with only 8 additional sub-markers characterized. Many of the previously described eight sub-markers are either very rare (2-4%) or do not distinguis...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lynn M Sims, Dennis Garvey, Jack Ballantyne
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4dcd1c4aa99a4f34b5fce8042aee164e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4dcd1c4aa99a4f34b5fce8042aee164e
record_format	dspace
spelling	oai:doaj.org-article:4dcd1c4aa99a4f34b5fce8042aee164e2021-11-25T06:22:18ZImproved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.1932-620310.1371/journal.pone.0005792https://doaj.org/article/4dcd1c4aa99a4f34b5fce8042aee164e2009-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19495413/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Y-SNP haplogroup G (hgG), defined by Y-SNP marker M201, is relatively uncommon in the United States general population, with only 8 additional sub-markers characterized. Many of the previously described eight sub-markers are either very rare (2-4%) or do not distinguish between major populations within this hg. In fact, prior to the current study, only 2% of our reference Caucasian population belonged to hgG and all of these individuals were in sub-haplogroup G2a, defined by P15. Additional Y-SNPs are needed in order to differentiate between individuals within this haplogroup.<h4>Principal findings</h4>In this work we have investigated whether we could differentiate between a population of 63 hgG individuals using previously uncharacterized Y-SNPs. We have designed assays to test these individuals using all known hgG SNPs (n = 9) and an additional 16 unreported/undefined Y-SNPS. Using a combination of DNA sequence and genetic genealogy databases, we have uncovered a total of 15 new hgG SNPs that had been previously reported but not phylogenetically characterized. Ten of the new Y-SNPs are phylogenetically equivalent to M201, one is equivalent to P15 and, interestingly, four create new, separate haplogroups. Three of the latter are more common than many of the previously defined Y-SNPs. Y-STR data from these individuals show that DYS38512 is present in (70%) of G2a3b1-U13 individuals while only 4% of non-G2a3b1-U13 individuals posses the DYS38512 allele.<h4>Conclusions</h4>This study uncovered several previously undefined Y-SNPs by using data from several database sources. The new Y-SNPs revealed in this paper will be of importance to those with research interests in population biology and human evolution.Lynn M SimsDennis GarveyJack BallantynePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 6, p e5792 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lynn M Sims Dennis Garvey Jack Ballantyne Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.
description	<h4>Background</h4>Y-SNP haplogroup G (hgG), defined by Y-SNP marker M201, is relatively uncommon in the United States general population, with only 8 additional sub-markers characterized. Many of the previously described eight sub-markers are either very rare (2-4%) or do not distinguish between major populations within this hg. In fact, prior to the current study, only 2% of our reference Caucasian population belonged to hgG and all of these individuals were in sub-haplogroup G2a, defined by P15. Additional Y-SNPs are needed in order to differentiate between individuals within this haplogroup.<h4>Principal findings</h4>In this work we have investigated whether we could differentiate between a population of 63 hgG individuals using previously uncharacterized Y-SNPs. We have designed assays to test these individuals using all known hgG SNPs (n = 9) and an additional 16 unreported/undefined Y-SNPS. Using a combination of DNA sequence and genetic genealogy databases, we have uncovered a total of 15 new hgG SNPs that had been previously reported but not phylogenetically characterized. Ten of the new Y-SNPs are phylogenetically equivalent to M201, one is equivalent to P15 and, interestingly, four create new, separate haplogroups. Three of the latter are more common than many of the previously defined Y-SNPs. Y-STR data from these individuals show that DYS38512 is present in (70%) of G2a3b1-U13 individuals while only 4% of non-G2a3b1-U13 individuals posses the DYS38512 allele.<h4>Conclusions</h4>This study uncovered several previously undefined Y-SNPs by using data from several database sources. The new Y-SNPs revealed in this paper will be of importance to those with research interests in population biology and human evolution.
format	article
author	Lynn M Sims Dennis Garvey Jack Ballantyne
author_facet	Lynn M Sims Dennis Garvey Jack Ballantyne
author_sort	Lynn M Sims
title	Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.
title_short	Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.
title_full	Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.
title_fullStr	Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.
title_full_unstemmed	Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.
title_sort	improved resolution haplogroup g phylogeny in the y chromosome, revealed by a set of newly characterized snps.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/4dcd1c4aa99a4f34b5fce8042aee164e
work_keys_str_mv	AT lynnmsims improvedresolutionhaplogroupgphylogenyintheychromosomerevealedbyasetofnewlycharacterizedsnps AT dennisgarvey improvedresolutionhaplogroupgphylogenyintheychromosomerevealedbyasetofnewlycharacterizedsnps AT jackballantyne improvedresolutionhaplogroupgphylogenyintheychromosomerevealedbyasetofnewlycharacterizedsnps
_version_	1718413800228519936

Improved resolution haplogroup G phylogeny in the Y chromosome, revealed by a set of newly characterized SNPs.

Ejemplares similares